SynthesisEndocrine2017
Hypertensive disorders during pregnancy and risk of type 2 diabetes in later life: a systematic review and meta-analysis.
Synthesis in Endocrine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 4 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- 2026 AHA/ACC/ADA/ASN Guideline for the Prevention, Detection, Evaluation, and Management of Cardiovascular-Kidney-Metabolic Syndrome: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.Journal of the American College of Cardiology · 2026Guideline
- Association between pregnancy-related complications and development of type 2 diabetes and hypertension in women: an umbrella review.BMC medicine · 2024Pooled it
- Economic Evaluation of Prenatal and Postpartum Care in Women With Gestational Diabetes and Hypertensive Disorders of Pregnancy: A Systematic Review.Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research · 2022Pooled it
- Risk of type 2 diabetes mellitus in women with prior hypertensive disorders of pregnancy: a systematic review and meta-analysis.Diabetologia · 2021Pooled it
- Global evidence on risk factors for the progression of gestational diabetes to type 2 diabetes: an umbrella review of systematic reviews and meta-analyses.Diabetology & metabolic syndrome · 2026Review
- Adverse pregnancy outcomes, familial predisposition, and cardiovascular risk: a Swedish nationwide study.European heart journal · 2025Article
- Preeclampsia-Associated Cardiovascular Risk Factors 6 Months and 2 Years After Pregnancy: The P4 Study.Hypertension (Dallas, Tex. : 1979) · 2024Article
- Sex differences in hypertension. Do we need a sex-specific guideline?Frontiers in cardiovascular medicine · 2022Review
- Sodium ozagrel and atorvastatin for type 2 diabetes patients with lacunar cerebral infarction.World journal of diabetes · 2021Article
- Team-Based Care of Women With Cardiovascular Disease From Pre-Conception Through Pregnancy and Postpartum: JACC Focus Seminar 1/5.Journal of the American College of Cardiology · 2021Review
- Association between neonatal birthweight and risk of maternal glucose intolerance after gestational diabetes mellitus.Journal of diabetes investigation · 2021Observational
- Dietary patterns and gestational hypertension in nulliparous pregnant Chinese women: A CONSORT report.Medicine · 2020Observational
- Involvement of Receptor for Advanced Glycation Endproducts in Hypertensive Disorders of Pregnancy.International journal of molecular sciences · 2019Article
- Hypertensive disorders of pregnancy increase the risk of developing neovascular age-related macular degeneration in later life.Hypertension in pregnancy · 2019Article
- Fasting blood glucose level and hypertension risk in aging benign prostatic hyperplasia patients.Aging · 2019Observational
- Midlife development of type 2 diabetes and hypertension in women by history of hypertensive disorders of pregnancy.Cardiovascular diabetology · 2018Article
- Postpartum glucose intolerance: an updated overview.Endocrine · 2018Review
- Postpartum Sequelae of the Hypertensive Diseases of Pregnancy: A Pilot Study.Nigerian medical journal : journal of the Nigeria Medical AssociationArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many studies assessed the association between hypertensive disorders during pregnancy and risk of type 2 diabetes mellitus in later life, but contradictory findings were reported. A systemic review and meta-analysis was carried out to elucidate type 2 diabetes mellitus risk in women with hypertensive disorders during pregnancy. Pubmed, Embase, and Web of Science were searched for cohort or case-control studies on the association between hypertensive disorders during pregnancy and subsequent type 2 diabetes mellitus. Random-effect model was used to pool risk estimates. Bayesian meta-analysis was carried out to further estimate the type 2 diabetes mellitus risk associated with hypertensive disorders during pregnancy. Seventeen cohort or prospective matched case-control studies were finally included. Those 17 studies involved 2,984,634 women and 46,732 type 2 diabetes mellitus cases. Overall, hypertensive disorders during pregnancy were significantly correlated with type 2 diabetes mellitus risk (relative risk = 1.56, 95 % confidence interval 1.21-2.01, P = 0.001). Preeclampsia was significantly and independently correlated with type 2 diabetes mellitus risk (relative risk = 2.25, 95 % confidence interval 1.73-2.90, P < 0.001). In addition, gestational hypertension was also significantly and independently correlated with subsequent type 2 diabetes mellitus risk (relative risk = 2.06, 95 % confidence interval 1.57-2.69, P < 0.001). The pooled estimates were not significantly altered in the subgroup analyses of studies on preeclampsia or gestational hypertension. Bayesian meta-analysis showed the relative risks of type 2 diabetes mellitus risk for individuals with hypertensive disorders during pregnancy, preeclampsia, and gestational hypertension were 1.59 (95 % credibility interval: 1.11-2.32), 2.27 (95 % credibility interval: 1.67-2.97), and 2.06 (95 % credibility interval: 1.41-2.84), respectively. Publication bias was not evident in the meta-analysis. Preeclampsia and gestational hypertension are independently associated with substantially elevated risk of type 2 diabetes mellitus in later life.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.