Evidence map›Paper›PMID 27518165›Full record

ArticleCancer2016

Patient function, long-term survival, and use of surgery in patients with kidney cancer.

Hung-Jui Tan, Karim Chamie, Timothy J Daskivich, Mark S Litwin, Jim C Hu

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
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  9. Noncardiac-Related Morbidity, Mobility Limitation, and Outcomes in Older Adults With Heart Failure.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Hung-Jui TanDepartment of Urology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Karim ChamieDepartment of Urology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California.
Timothy J DaskivichDivision of Urology, Cedars-Sinai Medical Center, Los Angeles, California.
Mark S LitwinDepartment of Urology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California.
Jim C HuDepartment of Urology, Weill Cornell School of Medicine, New York, New York.
University of California, Los Angeles · USCedars-Sinai Medical Center · USCornell University · USUniversity of North Carolina at Chapel Hill · US

Funding

NIA NIH HHS L30 AG051183
6 · The paper itself

Abstract

backgroundBeyond age and comorbidity, functionality can shape the long-term survival potential of patients with cancer. Accordingly, herein the authors compared mortality and receipt of cancer-directed surgery according to patient function among older adults with kidney cancer.

methodsUsing Surveillance, Epidemiology, and End Results (SEER)-Medicare data from 2000 through 2009, the authors studied 28,326 elderly subjects with primary kidney cancer. Patient function was quantified using function-related indicators, claims indicative of dysfunction and disability. Adjusting for patient and cancer characteristics, competing risk regression was used to assess the relationship between function-related indicator count and cause-specific mortality and then generalized estimating equations were used to quantify the probability of surgery.

resultsA total of 13,619 adult patients (48.1%) with at least 1 function-related indicator were identified. A higher indicator category was associated with older age, greater comorbidity, female sex, unmarried status, lower socioeconomic status, and higher stage of disease (P<.001). Compared with patients with an indicator count of 0, those with an indicator count of 1 (hazard ratio, 1.10; 95% confidence interval [95% CI], 1.04-1.16) and ≥2 (hazard ratio, 1.46; 95% CI, 1.39-1.53) were found to have higher other-cause mortality. Conversely, kidney cancer mortality varied minimally with patient function. Patients with ≥ 2 indicators received cancer-directed surgery less often than those without disability (odds ratio, 0.61; 95% CI, 0.56-0.66), although treatment probabilities remained high for patients with locoregional disease and low for those with metastatic cancer.

conclusionsAmong older adults with kidney cancer, functional health stands as a significant predictor of long-term survival. However, receipt of cancer-directed surgery appears largely determined by cancer stage. Patient function should be considered more heavily when determining treatment for older adults with kidney cancer. Cancer 2016;122:3776-3784. © 2016 American Cancer Society.

Indexed as

AgedAged, 80 and overComorbidityFemaleHumansKidney NeoplasmsMaleNeoplasm StagingOdds RatioProportional Hazards ModelsRisk FactorsSEER ProgramSocial Classagedfunctional statuskidney neoplasmnephrectomysurvival

Identifiers

PMID27518165
PMCPMC6156784
OpenAlexW2507949456

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.