Evidence map›Paper›PMID 27518161›Full record

ArticleAmerican journal of respiratory and critical care medicine2017

Maternal Folate Intake during Pregnancy and Childhood Asthma in a Population-based Cohort.

Christine L Parr, Maria C Magnus, Øystein Karlstad, Margaretha Haugen, Helga Refsum, Per M Ueland, Adrian McCann, Per Nafstad, Siri E Håberg, Wenche Nystad and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of respiratory and critical care medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 4 pooled it
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 4 syntheses or guidelines pooled it, 58 citations in OpenAlex.

  1. Dietary factors during pregnancy and atopic outcomes in childhood: A systematic review from the European Academy of Allergy and Clinical Immunology.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2020
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  14. Scientific opinion on the tolerable upper intake level for folate.EFSA journal. European Food Safety Authority · 2023
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  16. Periconceptional folic acid supplementation and child asthma: aThe journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2022
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 3 countries.

Christine L Parr1 Department of Mental and Physical Health and.ORCID 0000-0002-4690-0085
Maria C Magnus1 Department of Mental and Physical Health and.
Øystein Karlstad1 Department of Mental and Physical Health and.
Margaretha Haugen5 Department of Exposure and Risk Assessment, Norwegian Institute of Public Health, Oslo, Norway.
Helga Refsum6 Institute of Basic Medical Sciences, Department of Nutrition, and.
Per M Ueland7 Department of Clinical Science, University of Bergen, Bergen, Norway.
Adrian McCann9 Bevital AS, Bergen, Norway.
Per Nafstad1 Department of Mental and Physical Health and.
Siri E Håberg1 Department of Mental and Physical Health and.
Wenche Nystad1 Department of Mental and Physical Health and.
Stephanie J London2 Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina.
Norwegian Institute of Public Health · NONational Institutes of Health · USBevital (Norway) · NOHaukeland University Hospital · NOUniversity of Oslo · NO

Funding

Gene-Environment Interactions in an Autism Birth CohortU01NS047537 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LIPKIN, W. IAN · 2003 to 2013
$27.0M
Genetic And Environmental Factors In Childhood Respiratory HealthZIAES049019 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI LONDON, STEPHANIE · 2009 to 2025
$6.8M
GENETIC AND ENVIRONMENTAL FACTORS IN CHILDHOOD RESPIRATORY HEALTHZ01ES049019 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI LONDON, STEPHANIE JOAN · 1996 to 2008
$537k
Intramural NIH HHS Z01 ES049019NIEHS NIH HHS N01 ES075558NINDS NIH HHS U01 NS047537
6 · The paper itself

Abstract

rationaleA potential adverse effect of high folate intake during pregnancy on children's asthma development remains controversial.

objectivesTo prospectively investigate folate intake from both food and supplements during pregnancy and asthma at age 7 years when the diagnosis is more reliable than at preschool age.

methodsThis study included eligible children born 2002-2006 from the Norwegian Mother and Child Cohort Study, a population-based pregnancy cohort, linked to the Norwegian Prescription Database. Current asthma at age 7 was defined by asthma medications dispensed at least twice in the year (1,901 cases; n = 39,846) or by maternal questionnaire report (1,624 cases; n = 28,872). Maternal folate intake was assessed with a food frequency questionnaire validated against plasma folate. We used log-binomial and multinomial regression to calculate adjusted relative risks with 95% confidence intervals. MEASUREMENTS AND MAIN

resultsRisk of asthma was increased in the highest versus lowest quintile of total folate intake with an adjusted relative risk of 1.23 (95% confidence interval, 1.06-1.44) that was similar for maternally reported asthma. Mothers in the highest quintile had a relatively high intake of food folate (median, 308; interquartile range, 241-366 μg/d) and nearly all took at least 400 μg/d of supplemental folic acid (median, 500; interquartile range, 400-600 μg/d).

conclusionsIn this large prospective population-based cohort with essentially complete follow-up, pregnant women taking supplemental folic acid at or above the recommended dose, combined with a diet rich in folate, reach a total folate intake level associated with a slightly increased risk of asthma in children.

Indexed as

AdultAsthmaChildDietary SupplementsFemaleFolic AcidHumansMaleNorwayPregnancyPrenatal Exposure Delayed EffectsProspective StudiesRisk FactorsSurveys and QuestionnairesFolic Acidbirth cohortchildren’s asthma developmentepidemiologyfolic acidmaternal diet

Identifiers

PMID27518161
PMCPMC5394786
OpenAlexW2517514286

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.