Evidence map›Paper›PMID 27518087›Full record

ArticleNeurochemical research2017

CD38 Knockout Mice Show Significant Protection Against Ischemic Brain Damage Despite High Level Poly-ADP-Ribosylation.

Aaron Long, Ji H Park, Nina Klimova, Carol Fowler, David J Loane, Tibor Kristian

Open access · greenAbstract read
In one paragraph

Article in Neurochemical research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. CD38 connects the heart and brain.Translational psychiatry · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. NADGenes · 2021
    Review
  16. NADNature reviews. Molecular cell biology · 2021
    Review
  17. Role of NADBrain sciences · 2020
    Review
  18. NADExperimental neurology · 2020
    Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Aaron LongVeterans Affairs Maryland Health Care System, 10 North Greene Street, Baltimore, MD, 21201, USA.
Ji H ParkVeterans Affairs Maryland Health Care System, 10 North Greene Street, Baltimore, MD, 21201, USA.
Nina KlimovaDepartment of Anesthesiology, Center for Shock, Trauma and Anesthesiology Research, School of Medicine, University of Maryland, 685 West Baltimore Street, MSTF 534, Baltimore, MD, 21201, USA.
Carol FowlerVeterans Affairs Maryland Health Care System, 10 North Greene Street, Baltimore, MD, 21201, USA.
David J LoaneDepartment of Anesthesiology, Center for Shock, Trauma and Anesthesiology Research, School of Medicine, University of Maryland, 685 West Baltimore Street, MSTF 534, Baltimore, MD, 21201, USA.
Tibor KristianVeterans Affairs Maryland Health Care System, 10 North Greene Street, Baltimore, MD, 21201, USA. tkristian@anes.umm.edu.
University of Maryland, Baltimore · USVA Maryland Health Care System · US

Funding

Microglial activation phenotypes and mechanisms of repair in the aged TBI brainR01NS082308 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI LOANE, DAVID J. · 2013 to 2016
$1.4M
Nudix hydrolases and mitochondrial dynamics in acute neurodegenerative diseaseI01BX000917 · VA · BALTIMORE VA MEDICAL CENTER · PI KRISTIAN, TIBOR · 2011 to 2019
–
BLRD VA I01 BX000917NINDS NIH HHS R01 NS082308
6 · The paper itself

Abstract

Several enzymes in cellular bioenergetics metabolism require NAD

Indexed as

ADP-ribosyl Cyclase 1AnimalsBrain IschemiaCells, CulturedGlycoside HydrolasesHippocampusMaleMembrane GlycoproteinsMiceMice, Inbred C57BLMice, KnockoutPoly Adenosine Diphosphate RiboseRandom AllocationADP-ribosyl Cyclase 1Cd38 protein, mouseGlycoside HydrolasesMembrane GlycoproteinsPoly Adenosine Diphosphate Ribosepoly ADP-ribose glycohydrolaseBrainDamageIschemiaMouseNicotinamide dinucleotidePoly-ADP-ribose

Identifiers

PMID27518087
PMCPMC5580240
OpenAlexW2514539965

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.