Evidence map›Paper›PMID 27518079›Full record

ArticlePediatric radiology2016

The role of MR imaging in investigating isolated pediatric nystagmus.

Vaishnavi Batmanabane, Elise Heon, Tianyang Dai, Prakash Muthusami, Shiyi Chen, Arun Reginald, Shilpa Radhakrishnan, Manohar Shroff

Abstract read
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In one paragraph

Article in Pediatric radiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Vaishnavi BatmanabaneDepartment of Ophthalmology, The Hospital for Sick Children, 555 University Ave., Toronto, ON, M5G 1X8, Canada. vaishnavi.batmanabane@sickkids.ca.
Elise HeonDepartment of Ophthalmology, The Hospital for Sick Children, 555 University Ave., Toronto, ON, M5G 1X8, Canada.
Tianyang DaiDepartment of Ophthalmology, The Hospital for Sick Children, 555 University Ave., Toronto, ON, M5G 1X8, Canada.
Prakash MuthusamiDepartment of Diagnostic Imaging, The Hospital for Sick Children, Toronto, ON, Canada.
Shiyi ChenDepartment of Clinical Research Services, The Hospital for Sick Children, Toronto, ON, Canada.
Arun ReginaldDepartment of Ophthalmology, The Hospital for Sick Children, 555 University Ave., Toronto, ON, M5G 1X8, Canada.
Shilpa RadhakrishnanDepartment of Diagnostic Imaging, The Hospital for Sick Children, Toronto, ON, Canada.
Manohar ShroffDepartment of Diagnostic Imaging, The Hospital for Sick Children, Toronto, ON, Canada.
Hospital for Sick Children · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe use of MRI in isolated pediatric nystagmus remains a gray area in clinical management. Many clinicians prefer to order an MRI to rule out intracranial pathology despite the lack of clinically significant findings in most cases.

objectiveTo assess the yield of MR imaging in isolated pediatric nystagmus and define a management algorithm to minimize avoidable MRI referrals and streamline MRI protocols. MATERIALS AND

methodsWe reviewed the charts of 148 children who underwent neuro MRI for isolated nystagmus between January 2008 and September 2014. We noted nystagmus onset and clinical characteristics and compared them with the MRI features and visual electrophysiology results.

resultsWe included 85 boys and 63 girls (total 148, average age at MRI 4.24 ± 4.19 years). Twenty-three (15.5%) children had abnormal intracranial findings on MRI including abnormal signal lesions (4.1%; n=6), Chiari I malformations (3.4%; n=5) and optic pathway glioma (2.0%; n=3). The time of onset of nystagmus was not associated with an abnormal MRI (P=0.2). Seventy children underwent visual electrophysiology testing but this test could not predict abnormality at MRI, either (P=0.12).

conclusionAmong children with isolated nystagmus, 15.5% had abnormalities on neuroimaging. Neither clinical characteristics of nystagmus nor the visual electrophysiology results allowed prediction of intracranial pathology. We were unable to formulate a management algorithm for the optimal sequence of investigations (MRI preceding visual electrophysiology or vice versa), but we discuss the use of gadolinium contrast agent and orbital sequences in isolated pediatric nystagmus.

Indexed as

AdolescentChildChild, PreschoolEyeFemaleHumansInfantMagnetic Resonance ImagingMaleNystagmus, PathologicRetrospective StudiesBrainCentral nervous systemChildrenMagnetic resonance imagingNystagmusOrbitVisual electrophysiology

Identifiers

PMID27518079
OpenAlexW2513678387

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.