ArticleInternational journal of molecular sciences2016
Essential Oil of Cymbopogon nardus (L.) Rendle: A Strategy to Combat Fungal Infections Caused by Candida Species.
Article in International journal of molecular sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Monodisperse oligo(ε-caprolactones) with terpenes and alkyl end-groups: synthesis, isolation, characterization, and antibacterial activity.RSC advances · 2025Article
- Overcoming antifungal resistance inFrontiers in cellular and infection microbiology · 2025Review
- Unveiling the mechanism of essential oil action against skin pathogens: from ancient wisdom to modern science.Archives of microbiology · 2024Review
- Biological Activity of Biosynthesized Silver Nanoaggregates Prepared from the Aqueous Extract ofNanomaterials (Basel, Switzerland) · 2023Article
- Recent Progress and Trends in the Development of Electrospun and 3D Printed Polymeric-Based Materials to Overcome Antimicrobial Resistance (AMR).Pharmaceutics · 2023Review
- Essential Oil Composition Analysis ofMolecules (Basel, Switzerland) · 2023Article
- Essential Oils and Their Compounds as Potential Anti-Influenza Agents.Molecules (Basel, Switzerland) · 2022Review
- The antifungal and antibiofilm activity of Cymbopogon nardus essential oil and citronellal on clinical strains of Candida albicans.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2022Article
- Antifungal and Antiaflatoxinogenic Effects ofJournal of fungi (Basel, Switzerland) · 2022Article
- In Vitro and In Vivo Antidiabetic Potential of Monoterpenoids: An Update.Molecules (Basel, Switzerland) · 2021Review
- A Novel qNMR Application for the Quantification of Vegetable Oils Used as Adulterants in Essential Oils.Molecules (Basel, Switzerland) · 2021Article
- Plant Preparations and Compounds with Activities against Biofilms Formed byJournal of fungi (Basel, Switzerland) · 2021Review
- Improved in vitro and in vivo Anti-International journal of nanomedicine · 2020Article
- A Newly IsolatedFrontiers in microbiology · 2020Article
- Antifungal Activity of Essential Oils Against Candida Species Isolated from Clinical Samples.Mycopathologia · 2019Article
- Fungicidal PMMA-Undecylenic Acid Composites.International journal of molecular sciences · 2018Article
- Review
- Candida albicans/Staphylococcus aureus Dual-Species Biofilm as a Target for the Combination of Essential Oils and Fluconazole or Mupirocin.Mycopathologia · 2017Article
- Essential Oils and Antifungal Activity.Pharmaceuticals (Basel, Switzerland) · 2017Review
- Antifungal Resistance, Metabolic Routes as Drug Targets, and New Antifungal Agents: An Overview about Endemic Dimorphic Fungi.Mediators of inflammation · 2017Review
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe incidence of fungal infections, especially those caused by Candida yeasts, has increased over the last two decades. However, the indicated therapy for fungal control has limitations. Hence, medicinal plants have emerged as an alternative in the search for new antifungal agents as they present compounds, such as essential oils, with important biological effects. Published data demonstrate important pharmacological properties of the essential oil of Cymbopogon nardus (L.) Rendle; these include anti-tumor, anti-nociceptive, and antibacterial activities, and so an investigation of this compound against pathogenic fungi is interesting.
objectiveThe aim of this study was to evaluate the chemical composition and biological potential of essential oil (EO) obtained from the leaves of C. nardus focusing on its antifungal profile against Candida species.
methodsThe EO was obtained by hydrodistillation and analyzed by gas chromatography-mass spectrometry (GC-MS). Testing of the antifungal potential against standard and clinical strains was performed by determining the minimal inhibitory concentration (MIC), time-kill, inhibition of Candida albicans hyphae growth, and inhibition of mature biofilms. Additionally, the cytotoxicity was investigated by the IC50 against HepG-2 (hepatic) and MRC-5 (fibroblast) cell lines.
resultsAccording to the chemical analysis, the main compounds of the EO were the oxygen-containing monoterpenes: citronellal, geranial, geraniol, citronellol, and neral. The results showed important antifungal potential for all strains tested with MIC values ranging from 250 to 1000 μg/mL, except for two clinical isolates of C. tropicalis (MIC > 1000 μg/mL). The time-kill assay showed that the EO inhibited the growth of the yeast and inhibited hyphal formation of C. albicans strains at concentrations ranging from 15.8 to 1000 μg/mL. Inhibition of mature biofilms of strains of C. albicans, C. krusei and C. parapsilosis occurred at a concentration of 10× MIC. The values of the IC50 for the EO were 96.6 μg/mL (HepG-2) and 33.1 μg/mL (MRC-5).
conclusionAs a major virulence mechanism is attributed to these types of infections, the EO is a promising compound to inhibit Candida species, especially considering its action against biofilm.
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