Evidence map›Paper›PMID 27517726›Full record

ArticleTransplantation2016

Early Postoperative Pain and its Predictors in the Adult to Adult Living Donor Liver Transplantation Cohort Study.

M Susan Mandell, Abigail R Smith, Mary Amanda Dew, Debra B Gordon, Susan Holtzman, Terese Howell, Andrea F DiMartini, Zeeshan Butt, Mary Ann Simpson, Daniela P Ladner and 6 more

Registry-linked trialOpen access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Transplantation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01619475 (A2ALL), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01619475 completednot on this map

A2ALL: Adult-to-Adult Living Transplant Cohort Study

TypeobservationalSponsorArbor Research Collaborative for HealthRan2011 to 2014Enrolled1,871ConditionsLiver Diseases, Hepatocellular Cancer, End Stage Liver Disease, Hepatitis C
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 23 citations in OpenAlex.

  1. Trial
  2. Fatigue, Pain, and Other Physical Symptoms of Living Liver Donors in the Adult-to-Adult Living Donor Liver Transplantation Cohort Study.Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society · 2018
    Observational
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 1 institution in 1 country.

M Susan Mandell1 Department of Anesthesiology, University of Colorado, Boulder, CO. 2 Department of Biostatistics, University of Michigan, Ann Arbor, MI. 3 Arbor Research Collaborative for Health, Ann Arbor, MI. 4 Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA. 5 Department of Psychology, University of Pittsburgh, Pittsburgh, PA. 6 Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA. 7 Department of Biostatistics, University of Pittsburgh, Pittsburgh, PA. 8 Department of Anesthesiology, University of Washington, Seattle, WA. 9 Department of Psychology, University of British Columbia, Vancouver, BC, Canada. 10 Department of Surgery, University of Michigan, Ann Arbor, MI. 11 Department of Surgery, University of Pittsburgh, Pittsburgh, PA. 12 Department of Medical Social Sciences, Northwestern University, Feinberg School of Medicine, Chicago IL. 13 Department of Transplantation, Lahey Clinic, Burlington, MA. 14 Northwestern University Transplant Outcomes Research Collaborative, Northwestern University Feinberg School of Medicine, Chicago, IL. 15 Department of Surgery, University of California at San Francisco, San Francisco, CA. 16 Department of Anesthesia and Pain Management, Toronto General Hospital, Toronto, ON, Canada. 17 Department of Transplant Surgery, Virginia Commonwealth University, Richmond, VA. 18 Department of Surgery, College of Physicians and Surgeons, Columbia University, New York, NY. 19 Department of Surgery, University of Pennsylvania, Philadelphia, PA.
Abigail R Smith
Mary Amanda Dew
Debra B Gordon
Susan Holtzman
Terese Howell
Andrea F DiMartini
Zeeshan Butt
Mary Ann Simpson
Daniela P Ladner
Christopher E Freise
Stuart A McCluskey
Robert A Fisher
James V Guarrera
Kim M Olthoff
Elizabeth A Pomfret
University of Pittsburgh · US

Funding

Living donor liver transplant data coordinating centerU01DK062498 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MERION, ROBERT M · 2002 to 2016
$15.3M
Living Donor Liver Transplant - Predictive Models for Long-Term Health OutcomesU01DK062467 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ABECASSIS, MICHAEL M · 2002 to 2014
$4.7M
Living Donor Liver Transplant :Short & Long-Term Impact on Donors and RecipientsU01DK062444 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FREISE, CHRIS · 2002 to 2014
$3.7M
Adult to Adult Living Donor Liver Transplantation Cohort StudyU01DK062483 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI EMOND, JEAN C · 2002 to 2014
$3.5M
Adult to Adult Living Donor Liver Transplantation Cohort Study (A2ALL)U01DK062536 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI BURTON, JAMES · 2002 to 2013
$3.4M
Adult to Adult Living Donor Liver Transplantation Cohort StudyU01DK062494 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI OLTHOFF, KIM MARIE · 2002 to 2014
$3.3M
Adult to Adult Living Donor Liver TransplantationU01DK062531 · NIDDK · VIRGINIA COMMONWEALTH UNIVERSITY · PI COTTERELL, ADRIAN · 2002 to 2014
$2.7M
A2ALL Cohort Study: Pyschosocial and Surgical OutcomesU01DK085587 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HUMAR, ABHINAV · 2009 to 2014
$1.8M
University Health Network's Application to Join the A2ALL ConsortiumU01DK085563 · NIDDK · UNIVERSITY HEALTH NETWORK · PI GRANT, DAVID R · 2009 to 2014
$1.4M
LDLT: Diagnostic Markers of Liver Regeneration to Predict OutcomesU01DK085515 · NIDDK · LAHEY CLINIC · PI POMFRET, ELIZABETH A · 2009 to 2014
$1.1M
NIDDK NIH HHS U01 DK062444NIDDK NIH HHS U01 DK062467NIDDK NIH HHS U01 DK062483NIDDK NIH HHS U01 DK062494NIDDK NIH HHS U01 DK062498NIDDK NIH HHS U01 DK062531NIDDK NIH HHS U01 DK062536NIDDK NIH HHS U01 DK085515NIDDK NIH HHS U01 DK085563NIDDK NIH HHS U01 DK085587
6 · The paper itself

Abstract

backgroundLittle is known about how well postoperative pain is managed in living liver donors, despite pain severity being the strongest predictor of persistent pain with long-lasting disability.

methodsWe conducted a prospective multicenter study of 172 living liver donors. Self-reported outcomes for pain severity, activity interference, affective (emotional) reactions, adverse effects to treatment, and perceptions of care were collected using the American Pain Society Patient Outcomes Questionnaire-Revised. Mixed-effects linear regression was used to identify demographic and psychosocial predictors of subscale scores.

resultsDonors were young (36.8 ± 10.6) and healthy. Of 12 expert society analgesic recommendations for postoperative pain management, 49% received care conforming to 3 guidelines, and only 9% to 4 or 5. More than half reported adverse effects to analgesic treatment for moderate to severe pain that interfered with functional activity; however, emotional distress to pain was unexpectedly minimal. Female donors had higher affective (β = 0.88, P = 0.005) and adverse effects scores (β = 1.33, P < 0.001). Donors with 2 or more medical concerns before surgery averaged 1 unit higher pain severity, functional interference, adverse effects, and affective reaction subscale scores (β range 1.06-1.55, all P < 0.05). Receiving information about pain treatment options increased perception of care subscale scores (β = 1.24, P = 0.001), whereas depressive symptoms before donation were associated with lower scores (β = -1.58, P = 0.01).

conclusionsDonors have a distinct profile of pain reporting that is highly influenced by psychological characteristics. Interventions to improve pain control should consider modifying donor behavioral characteristics in addition to optimizing pain care protocols.

Indexed as

Liver TransplantationLiving DonorsAdolescentAdultFemaleHumansMaleMiddle AgedPostoperative PainProspective StudiesSurveys and QuestionnairesYoung Adult

Identifiers

PMID27517726
PMCPMC5077637
OpenAlexW2518325530

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.