Evidence map›Paper›PMID 27517680›Full record

Trial reportInternational journal of colorectal disease2016

The effects of fast-track surgery on inflammation and immunity in patients undergoing colorectal surgery.

Jinhua Feng, Ka Li, Li Li, Xiaodong Wang, Mingjun Huang, Jie Yang, Yanjie Hu

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in International journal of colorectal disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03793036 (A Randomized Controlled Study of Preoperative Oral Carbohydrate Loading Versus Fasting in Patients Undergoing Colorectal Surgery), which is not on this map. Cited by 10 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 5 pooled it
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03793036 nacompletednot on this mapstarted 2018, after this paper: background citation

A Randomized Controlled Study of Preoperative Oral Carbohydrate Loading Versus Fasting in Patients Undergoing Colorectal Surgery

TypeinterventionalSponsorNermina RizvanovićRan2018 to 2018Enrolled50ConditionsInsulin Resistance, Inflammatory Response, Exaggerated Well-Being, Length of StayArmspreoperative nutrition
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 5 syntheses or guidelines pooled it, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jinhua FengDepartment of Biliary Surgery, West China Hospital of Sichuan University, Chengdu, 610041, China.
Ka LiNursing Department, West China Hospital of Sichuan University, Chengdu, 610041, China. likalika127127@163.com.
Li LiDepartment of Gastrointestinal Surgery, West China Hospital of Sichuan University, Chengdu, 610041, China.
Xiaodong WangDepartment of Gastrointestinal Surgery, West China Hospital of Sichuan University, Chengdu, 610041, China.
Mingjun HuangNursing Department, West China Hospital of Sichuan University, Chengdu, 610041, China.
Jie YangDepartment of Gastrointestinal Surgery, West China Hospital of Sichuan University, Chengdu, 610041, China.
Yanjie HuWest China School of Nursing, Sichuan University, Chengdu, 610041, China.
West China Hospital of Sichuan University · CNSichuan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe objective of this study is to explore the effects of the fast-track surgery (FTS) program on inflammation and immunity in patients undergoing colorectal surgery.

methodsFrom August 2014 to March 2015, a prospective and randomized controlled trial of 230 patients who underwent colorectal surgery was performed. The patients were randomly assigned to an FTS group (116 patients) or a traditional group (114 patients). Inflammatory mediators, immunological indicators, postoperative recovery indexes, and complications were compared between the two groups.

resultsThe inflammatory mediators (CRP, IL-6, TNF-α) were lower in the FTS group than in the traditional group (P < 0.05) on postoperative day (POD) 1, POD 4, and POD 6, and the immunological indicators (IgG, IgA, C3, C4) of the FTS group were superior to those of the traditional group (P < 0.05) on POD 4 and POD 6. The time to first aerofluxus, defecation, oral intake, and ambulation after surgery was shorter in the FTS group than in the traditional group (P < 0.05); however, the duration of postoperative hospitalization did not differ significantly between the two groups (P > 0.05). The total complications were significantly lower in the FTS group than in the traditional group (P < 0.05).

conclusionThe FTS program can decrease inflammation, maintain immune homeostasis, and improve rehabilitation effects in colorectal surgery patients.

Indexed as

ImmunityColorectal SurgeryFemaleHumansInflammationInflammation MediatorsMaleMiddle AgedPostoperative ComplicationsPostoperative PeriodInflammation MediatorsColorectal cancerFast-track surgeryImmunityInflammationRehabilitation effects

Identifiers

PMID27517680
OpenAlexW2517364937

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.