ArticleClinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology2016
Higher maternal serum concentrations of nicotinamide and related metabolites in late pregnancy are associated with a lower risk of offspring atopic eczema at age 12 months.
Article in Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
- Tryptophan Metabolism at the Crossroads of Immunity, Barrier Function, and the Microbiome in Atopic Dermatitis.Clinical reviews in allergy & immunology · 2026Review
- Maternal Dietary Inflammatory Status and Serum Neopterin During Pregnancy: Influence on Infantile Atopic Eczema in the Offspring.Clinical and translational allergy · 2025Article
- Nicotinamide: A Multifaceted Molecule in Skin Health and Beyond.Medicina (Kaunas, Lithuania) · 2025Review
- Lymph food to improve canine atopic dermatitis: a randomized, double-blinded, controlled trial in dogs with standard-care treatment.Frontiers in veterinary science · 2025Article
- Iron deficiency in dogs suffering from atopic dermatitis.BMC veterinary research · 2024Article
- Exploring genetic associations between metabolites and atopic dermatitis: insights from bidirectional Mendelian randomization analysis in European population.Frontiers in nutrition · 2024Article
- Tryptophan as a biomarker of pregnancy-related immune expression and modulation: an integrative review.Frontiers in reproductive health · 2024Review
- Comparison of Growth Performance and Plasma Metabolomics between Two Sire-Breeds of Pigs in China.Genes · 2023Article
- Early life exposure to antibiotics and laxatives in relation to infantile atopic eczema.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2023Article
- Exploration of Metabolite Biomarkers to Predict the Efficacy of Dupilumab Treatment for Atopic Dermatitis.Disease markers · 2023Article
- Role of human milk oligosaccharide metabolizing bacteria in the development of atopic dermatitis/eczema.Frontiers in pediatrics · 2023Review
- Integrated metabolomics and lipidomics study of patients with atopic dermatitis in response to dupilumab.Frontiers in immunology · 2022Article
- Maternal Nutritional Status and Development of Atopic Dermatitis in Their Offspring.Clinical reviews in allergy & immunology · 2021Review
- Role of maternal tryptophan metabolism in allergic diseases in the offspring.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2021Article
- Roles of vitamins in stem cells.Cellular and molecular life sciences : CMLS · 2020Review
- Article
- Redox Properties of Tryptophan Metabolism and the Concept of Tryptophan Use in Pregnancy.International journal of molecular sciences · 2017Review
- Niacin intake and incident adult-onset atopic dermatitis in women.The Journal of allergy and clinical immunology · 2017Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundEvidence that atopic eczema partly originates in utero is increasing, with some studies linking the risk of developing the condition with aspects of maternal diet during pregnancy. Nicotinamide, a naturally occurring nutrient that is maintained through the dietary intakes of vitamin B3 and tryptophan, has been used in the treatment of some skin conditions including atopic eczema.
objectiveTo examine the relation of maternal serum concentrations of nicotinamide and related tryptophan metabolites to the risk of atopic eczema in the offspring.
methodsWithin the UK Southampton Women Survey, infantile atopic eczema at ages 6 and 12 months was ascertained (modified UK Working Party Criteria for the Definition of Atopic Dermatitis). Maternal serum levels of kynurenine, kynurenic acid, anthranilic acid, tryptophan, nicotinamide and N1-methylnicotinamide were measured in late pregnancy by mass spectrometry (n = 497) and related to the odds ratio of infantile atopic eczema.
resultsMaternal nicotinamide and related metabolite concentrations were not associated with offspring atopic eczema at age 6 months. Higher concentrations of nicotinamide and anthranilic acid were, however, associated with a lower risk of eczema at age 12 months (odds ratios 0.69, 95% CI 0.53-0.91/SD change, P = 0.007 and 0.63, 0.48-0.83, P = 0.001, respectively). The associations were robust to adjustment for potentially confounding variables. CONCLUSION AND CLINICAL RELEVANCE: This is the first study linking maternal serum concentrations of nicotinamide and related metabolites to the risk of atopic eczema in the offspring. The findings point to potentially modifiable maternal influences on this complex and highly prevalent condition.
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