Evidence map›Paper›PMID 27517351›Full record

ReviewCurrent opinion in microbiology2016

An intracellular compass spatially coordinates cell cycle modules in Caulobacter crescentus.

Keren Lasker, Thomas H Mann, Lucy Shapiro

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
8.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 82 citations in OpenAlex.

  1. Article
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  7. Coupling of cell growth modulation to asymmetric division and cell cycle regulation inProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  8. Article
  9. Review
  10. Article
  11. TheAnnual review of microbiology · 2023
    Review
  12. Article
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  14. Article
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Keren LaskerDepartment of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Thomas H MannDepartment of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305, USA.
Lucy ShapiroDepartment of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: shapiro@stanford.edu.
Stanford University · US

Funding

Supplement to Enhance Wellness and Resiliency in the Graduate EnvironmentT32GM007276 · NIGMS · STANFORD UNIVERSITY · PI MORRISON, ASHBY J. · 1985 to 2023
$32.9M
REGULATION OF DIFFERENTIATION IN CAULOBACTERR01GM032506 · NIGMS · YESHIVA UNIVERSITY · PI SHAPIRO, LUCILLE · 1985 to 2014
$7.1M
Integration of regulatory networks and subcellular architecture to control the Caulobacter cell cycleR35GM118071 · NIGMS · STANFORD UNIVERSITY · PI SHAPIRO, LUCILLE · 2016 to 2020
$3.2M
NIGMS NIH HHS R01 GM032506NIGMS NIH HHS R35 GM118071NIGMS NIH HHS T32 GM007276
6 · The paper itself

Abstract

Cellular functions in Bacteria, such as chromosome segregation and cytokinesis, result from cascades of molecular events operating largely as self-contained modules. Regulated timing of these cellular modules stems from global genetic circuits that allow precise temporal activation with respect to cell cycle progression and cell differentiation. Critically, many of these functions occur at defined locations within the cell, and therefore regulators of each module must communicate to remain coordinated in space. In this perspective, we highlight recent discoveries in Caulobacter crescentus asymmetric cell division to illuminate diverse mechanisms by which a cellular compass, composed of scaffolding and signaling proteins, directs cell cycle modules to their exact cellular addresses.

Indexed as

Bacterial ProteinsCaulobacter crescentusCell DivisionChromosome SegregationDNA, BacterialDNA-Binding ProteinsDNA ReplicationFlagellaGene Regulatory NetworksTranscription FactorsBacterial ProteinsCtrA protein, CaulobacterDNA, BacterialDNA-Binding ProteinsTranscription Factors

Identifiers

PMID27517351
PMCPMC5069156
OpenAlexW2501857680

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.