ReviewCurrent opinion in obstetrics & gynecology2016
Exploring the basic science of prolapse meshes.
Review in Current opinion in obstetrics & gynecology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07414849 (The Amper Study), which is not on this map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Amper Study: Amniotic Membrane for the Prevention of Mesh Exposure in Vaginal Reconstructive Surgery
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Animal experimental research assessing urogynecologic surgical mesh implants: Outcome measures describing the host response, a systematic review and meta-analysis.Neurourology and urodynamics · 2021Pooled it
- Macrophage-to-myofibroblast transition (MMT) - An adverse response to polypropylene mesh implanted for pelvic organ prolapse repair surgery in a non-human primate model.Biomaterials · 2026Article
- From Mesh to Modern Therapies: An Updated Narrative Review on Urogenital Prolapse.Journal of clinical medicine · 2025Review
- Macrophage-to-Myofibroblast Transition (MMT) - an adverse response to polypropylene mesh implanted for pelvic organ prolapse repair surgery in a non-human primate model.bioRxiv : the preprint server for biology · 2025Article
- Profiling of the macrophage response to polypropylene mesh burden in vivo.Biomaterials · 2025Article
- Long-Term Outcomes of Restorelle® Direct Fix Anterior Mesh in the Treatment of Pelvic Organ Prolapse.Cureus · 2024Article
- An in vitro pilot study investigating placenta-derived mesenchymal stem cell coating on polypropylene mesh materials.International urogynecology journal · 2024Article
- Dysregulated wound healing in the pathogenesis of urogynecologic mesh complications.Scientific reports · 2023Article
- Melt Electrospinning Writing of Mesh Implants for Pelvic Organ Prolapse Repair.3D printing and additive manufacturing · 2022Article
- Mesh exposure following minimally invasive sacrocolpopexy: a narrative review.International urogynecology journal · 2022Review
- Outcomes following sacrocolpopexy using ultralight and lightweight mesh.International urogynecology journal · 2022Article
- Complications Reported to the Food and Drug Administration: A Cross-sectional Comparison of Urogynecologic Meshes.Female pelvic medicine & reconstructive surgery · 2022Article
- Evaluation of the short-term host response and biomechanics of an absorbable poly-4-hydroxybutyrate scaffold in a sheep model following vaginal implantation.BJOG : an international journal of obstetrics and gynaecology · 2022Article
- Role of Fibroblasts and Myofibroblasts on the Pathogenesis and Treatment of Pelvic Organ Prolapse.Biomolecules · 2022Review
- Review
- Host-biomaterial interactions in mesh complications after pelvic floor reconstructive surgery.Nature reviews. Urology · 2021Review
- A novel characterisation approach to reveal the mechano-chemical effects of oxidation and dynamic distension on polypropylene surgical mesh.RSC advances · 2021Article
- Assessing pelvic organ prolapse recurrence after minimally invasive sacrocolpopexy: does mesh weight matter?International urogynecology journal · 2021Article
- Prospective ultrasonographic follow-up of transvaginal lightweight meshes: a 1-year multicenter study.International urogynecology journal · 2021Observational
- Distinct macrophage populations and phenotypes associated with IL-4 mediated immunomodulation at the host implant interface.Biomaterials science · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
purpose of reviewPolypropylene mesh has been widely used in the surgical repair of pelvic organ prolapse. However, low but persistent rates of complications related to mesh, most commonly mesh exposure and pain, have hampered its use. Complications are higher following transvaginal implantation prompting the Food and Drug Administration to release two public health notifications warning of complications associated with transvaginal mesh use (PHN 2008 and 2011) and to upclassify transvaginal prolapse meshes from Class II to Class III devices. Although there have been numerous studies to determine the incidence and management of mesh complications as well as impact on quality of life, few studies have focused on mechanisms. RECENT
findingsIn this review, we summarize the current understanding of how mesh textile properties and mechanical behavior impact vaginal structure and function, as well as the local immune response. We also discuss how mesh properties change in response to loading. SUMMARY: We highlight a few areas of current and future research to emphasize collaborative strategies that incorporate basic science research to improve patient outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.