Evidence map›Paper›PMID 27517280›Full record

ReviewJournal of medical toxicology : official journal of the American College of Medical Toxicology2016

The Toxicology Investigators Consortium Case Registry-the 2015 Experience.

Lynn A Farrugia, Sean H Rhyee, Sharan L Campleman, Anne-Michelle Ruha, Timothy Weigand, Paul M Wax, Jeffrey Brent, Toxicology Investigators Consortium

Open access · bronzeAbstract readReview
In one paragraph

Review in Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 26 citations in OpenAlex.

  1. The Toxicology Investigators Consortium 2024 Annual Report.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2026
    Article
  2. The Toxicology Investigators Consortium 2023 Annual Report.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2024
    Article
  3. From Patient Registry to Multi-Center Research Consortium: the Toxicology Investigators Consortium (ToxIC) Turns Fifteen.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2024
    Article
  4. The Toxicology Investigators Consortium 2022 Annual Report.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2023
    Article
  5. Article
  6. The Toxicology Investigators Consortium Case Registry-the 2019 Annual Report.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2020
    Article
  7. Article
  8. The Toxicology Investigators Consortium Case Registry-the 2018 Annual Report.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2019
    Article
  9. Article
  10. Article
  11. The Toxicology Investigators Consortium Case Registry-the 2017 Annual Report.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2018
    Article
  12. The Epidemiology, Clinical Course, and Management of Snakebites in the North American Snakebite Registry.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2017
    Article
  13. Ethics and Medical Toxicology Research.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2017
    Review
  14. The Toxicology Investigators Consortium Case Registry-the 2016 Experience.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 7 institutions in 1 country.

Lynn A FarrugiaHartford Hospital, 80 Seymour Street, Hartford, CT, 06102, USA. Lynn.Farrugia@hhchealth.org.
Sean H RhyeeSaint Francis Hospital and Medical Center, 114 Woodland St., Hartford, CT, 06105, USA.
Sharan L CamplemanAmerican College of Medical Toxicology, 10645 N. Tatum Blvd., Suite 200-111, Phoenix, AZ, 85028, USA.
Anne-Michelle RuhaBanner-University Medical Center Phoenix, 925 E. McDowell Rd, Phoenix, AZ, 85006, USA.
Timothy WeigandUniversity of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Rochester, NY, 14642, USA.
Paul M WaxUT Southwestern Medical School, 5323 Harry Hines Boulevard, Dallas, TX, 75390, USA.
Jeffrey BrentUniversity of Colorado School of Medicine, 13001 E 17th Pl., Aurora, CO, 80045, USA.
Toxicology Investigators Consortium
American College of Medical Toxicology · USBanner - University Medical Center Phoenix · USHartford Hospital · USSaint Francis Hospital & Medical Center · USThe University of Texas Southwestern Medical Center · USUniversity of Colorado Denver · USUniversity of Rochester · US

Funding

Prevention of the cardiovascular medical consequences of drug overdoseR01DA037317 · NIDA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MANINI, ALEX FRANCIS · 2014 to 2018
$3.6M
Pharmacotherapy to counterACT parathion-induced NMJ dysfunctionU01NS083452 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI GASPARI, ROMOLO J · 2013 to 2016
$2.9M
NIDA National Early Warning System Network (iN3): An Innovative ApproachR56DA038366 · NIDA · WRIGHT STATE UNIVERSITY · PI BOYER, EDWARD W, CARLSON, ROBERT GEOFFREY · 2014 to 2014
$300k
NIDA NIH HHS R01 DA037317NIDA NIH HHS R56 DA038366NINDS NIH HHS U01 NS083452
6 · The paper itself

Abstract

The American College of Medical Toxicology established the Toxicology Investigators Consortium (ToxIC) Case Registry in 2010. The Registry contains all medical toxicology consultations performed at participating sites. The Registry has continued to grow since its inception, and as of December 31, 2015, contains 43,099 cases. This is the sixth annual report of the ToxIC Registry, summarizing the additional 8115 cases entered in 2015. Cases were identified by a query of the Registry for all cases entered between January 1 and December 31, 2015. Specific data reviewed for analysis included demographics (age, race, gender), source of consultation, reason for consultation, agents and agent classes involved in exposures, signs, symptoms, clinical findings, fatalities, and treatment. By the end of 2015, there were 50 active sites, consisting of 101 separate health-care facilities; 51.2 % of cases involved females. Adults between the ages of 19 and 65 made up the majority (64.2 %) of Registry cases. Caucasian race was the most commonly reported (55.6 %); 9.6 % of cases were identified as Hispanic ethnicity. Inpatient and emergency department referrals were by far the most common referral sources (92.9 %). Intentional pharmaceutical exposures remained the most frequent reason for consultation, making up 52.3 % of cases. Of these intentional pharmaceutical exposures, 69 % represented an attempt at self-harm, and 85.6 % of these were a suicide attempt. Nonopioid analgesics, sedative-hypnotics, and antidepressant agents were the most commonly reported agent classes in 2015. Almost one-third of Registry cases involved a diagnosed toxidrome (32.8 %), with a sedative-hypnotic toxidrome being the most frequently described. Significant vital sign abnormalities were recorded in 25.3 % of cases. There were 98 fatalities reported in the Registry (1.2 %). Adverse drug reactions were reported in 4.3 % of cases. Toxicological treatment was given in 65.3 % of cases, with 33.0 % receiving specific antidotal therapy. Exposure characteristics and trends overall were similar to prior years. While treatment interventions were required in the majority of cases, fatalities were rare.

Indexed as

AdolescentAdultAnalgesics, Non-NarcoticAntidepressive AgentsAntidotesChildDrug OverdoseDrug-Related Side Effects and Adverse ReactionsHumansHypnotics and SedativesInfantPoisoningReferral and ConsultationRegistriesResearch PersonnelSentinel SurveillanceAnalgesics, Non-NarcoticAntidepressive AgentsAntidotesHypnotics and SedativesToxiferineEpidemiologyMedical toxicologyOverdosePoisoningsSurveillance

Identifiers

PMID27517280
PMCPMC4996797
OpenAlexW2915277209

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.