ArticleAvicenna journal of phytomedicine
Protective effect of Viola tricolor and Viola odorata extracts on serum/glucose deprivation-induced neurotoxicity: role of reactive oxygen species.
Article in Avicenna journal of phytomedicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Medicinal Plant-derived Phytochemicals in Detoxification.Current pharmaceutical design · 2024Review
- Edible Herbal Medicines as an Alternative to Common Medication for Sleep Disorders: A Review Article.Current neuropharmacology · 2024Review
- Phytochemical Classification of Medicinal Plants Used in the Treatment of Kidney Disease Based on Traditional Persian Medicine.Evidence-based complementary and alternative medicine : eCAM · 2022Review
- Effectiveness ofEvidence-based complementary and alternative medicine : eCAM · 2021Article
- Cyclotides Isolated From Violet Plants of Cameroon Are Inhibitors of Human Prolyl Oligopeptidase.Frontiers in pharmacology · 2021Article
- Potentials of Antitussive Traditional Persian Functional Foods for COVID-19 TherapyFrontiers in pharmacology · 2021Review
- Anticonvulsant Activity of Viola tricolor against Seizures Induced by Pentylenetetrazol and Maximal Electroshock in Mice.Iranian journal of medical sciences · 2019Article
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- AttenuatingBasic and clinical neuroscienceArticle
- Protective Effect of theBasic and clinical neuroscienceArticle
- Anorexia: Highlights in Traditional Persian medicine and conventional medicine.Avicenna journal of phytomedicineReview
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveOxidative stress plays a key role in the pathophysiology of brain ischemia and neurodegenerative disorders. Previous studies indicated that Viola tricolor and Viola odorata are rich sources of antioxidants. This study aimed to determine whether these plants protect neurons against serum/glucose deprivation (SGD)-induced cell death in an in vitro model of ischemia and neurodegeneration. METHODS AND MATERIAL: The PC12 neuronal cells were pretreated for 4 hr with 1 to 50 µg/ml of V. odorata or V. tricolor hydroalcoholic extracts followed by 24 hr incubation under SGD condition. Cell viability was evaluated by 4,5-dimethyl-2-thiazolyl-2,5-diphenyl-2H-tetrazolium bromide assay. The level of intracellular reactive oxygen species (ROS) was quantitated by flow cytometry using 2',7'- dichlorofluorescin diacetate as a probe.
resultsSGD condition led to significant decrease in cell viability (p<0.001). Pretreatment with both V. tricolor and V. odorata extracts reduced the SGD-induced cytotoxicity. SGD resulted in a significant increase in intracellular ROS production (p<0.001). Both extracts at concentrations of 25 and 50 µg/ml could reverse the increased ROS production (p<0.05).
conclusionResults of the present study showed that V. tricolor and V. odorata protect neuronal cells against SGD-induced cell death, at least in part, by their antioxidant activities. Further studies on the possible application of these plants in prevention or treatment of cerebral ischemia and neurodegenerative diseases seem to be warranted.
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Identifiers
27516984PMC4967839What OpenQuestion holds
Registered trials
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