ArticleNeural plasticity2016
The Habituation/Cross-Habituation Test Revisited: Guidance from Sniffing and Video Tracking.
Article in Neural plasticity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 37 citations in OpenAlex.
- Modelling Olfactory Dysfunction in Rodents Through Intranasal Vanadium Exposure.Animals : an open access journal from MDPI · 2026Review
- Behavioral deficits and exacerbated neural and hemodynamic odor responses during lifespan of a mouse model of late onset Alzheimer's disease expressing humanized APOEε4 and Trem2*R47H.Frontiers in aging neuroscience · 2026Article
- Behaviour of ewes and lambs in response to human emotional odours.Scientific reports · 2025Article
- Sex-Specific Behavioral Features of the Prenatal Valproic Acid Rat Model of Autism Spectrum Disorder.Brain sciences · 2025Article
- Do sheep (Ovis aries) discriminate human emotional odors?Animal cognition · 2024Article
- Wireless monitoring of respiration with EEG reveals relationships between respiration, behavior, and brain activity in freely moving mice.Journal of neurophysiology · 2024Article
- Amelioration of Cognitive and Olfactory System Deficits in APOE4 Transgenic Mice with DHA Treatment.Molecular neurobiology · 2023Article
- Horse odor exploration behavior is influenced by pregnancy and age.Frontiers in behavioral neuroscience · 2022Article
- Olfactory impairment in men and mice related to aging and amyloid-induced pathology.Pflugers Archiv : European journal of physiology · 2021Review
- The functional relevance of olfactory marker protein in the vertebrate olfactory system: a never-ending story.Cell and tissue research · 2021Review
- An automated sensitive approach for measuring whole gut transit time.Neurogastroenterology and motility · 2020Article
- Partial depletion of dopaminergic neurons in the substantia nigra impairs olfaction and alters neural activity in the olfactory bulb.Scientific reports · 2019Article
- Modulation of olfactory-driven behavior by metabolic signals: role of the piriform cortex.Brain structure & function · 2019Article
- Fus1 KO Mouse As a Model of Oxidative Stress-Mediated Sporadic Alzheimer's Disease: Circadian Disruption and Long-Term Spatial and Olfactory Memory Impairments.Frontiers in aging neuroscience · 2016Article
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Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
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Abstract
The habituation/cross-habituation test (HaXha) is a spontaneous odor discrimination task that has been used for many decades to evaluate olfactory function in animals. Animals are presented repeatedly with the same odorant after which a new odorant is introduced. The time the animal explores the odor object is measured. An animal is considered to cross-habituate during the novel stimulus trial when the exploration time is higher than the prior trial and indicates the degree of olfactory patency. On the other hand, habituation across the repeated trials involves decreased exploration time and is related to memory patency, especially at long intervals. Classically exploration is timed using a stopwatch when the animal is within 2 cm of the object and aimed toward it. These criteria are intuitive, but it is unclear how they relate to olfactory exploration, that is, sniffing. We used video tracking combined with plethysmography to improve accuracy, avoid observer bias, and propose more robust criteria for exploratory scoring when sniff measures are not available. We also demonstrate that sniff rate combined with proximity is the most direct measure of odorant exploration and provide a robust and sensitive criterion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.