ArticleAdvanced functional materials2015
Protein Corona Influences Cell-Biomaterial Interactions in Nanostructured Tissue Engineering Scaffolds.
Article in Advanced functional materials, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.
- Engineering Functional Cardiac Tissues for Regenerative Medicine Applications.Current cardiology reports · 2019Pooled it
- Differential Neutrophil Responses to Smooth Titanium: A Double-Edged Sword for the Abutment-Gingival Interface (An In Vitro Study).International journal of dentistry · 2026Article
- Advances in Conductive Biomaterials for Cardiac Tissue Engineering: Design, Fabrication, and Functional Integration.Polymers · 2025Review
- A Comprehensive Review of Nanoparticles: From Classification to Application and Toxicity.Molecules (Basel, Switzerland) · 2024Review
- Navigating the combinations of platelet-rich fibrin with biomaterials used in maxillofacial surgery.Frontiers in bioengineering and biotechnology · 2024Review
- Multifunctional dendrimer@nanoceria engineered GelMA hydrogel accelerates bone regeneration through orchestrated cellular responses.Materials today. Bio · 2023Article
- A Comprehensive Review on Collagen Type I Development of Biomaterials for Tissue Engineering: From Biosynthesis to Bioscaffold.Biomedicines · 2022Review
- Functionalisation of Inorganic Material Surfaces with Staphylococcus Protein A: A Molecular Dynamics Study.International journal of molecular sciences · 2022Article
- Engineered Nanoparticle-Protein Interactions Influence Protein Structural Integrity and Biological Significance.Nanomaterials (Basel, Switzerland) · 2022Review
- Implantable Drug Delivery Systems and Foreign Body Reaction: Traversing the Current Clinical Landscape.Bioengineering (Basel, Switzerland) · 2021Review
- Host-biomaterial interactions in mesh complications after pelvic floor reconstructive surgery.Nature reviews. Urology · 2021Review
- Effect of tissue microenvironment on fibrous capsule formation to biomaterial-coated implants.Biomaterials · 2021Article
- Protein nanoparticles in drug delivery: animal protein, plant proteins and protein cages, albumin nanoparticles.Journal of nanobiotechnology · 2021Review
- Can nanoparticles and nano‒protein interactions bring a bright future for insulin delivery?Acta pharmaceutica Sinica. B · 2021Review
- Tailoring the component of protein corona via simple chemistry.Nature communications · 2019Article
- Engineering precision biomaterials for personalized medicine.Science translational medicine · 2018Review
- Infection-resistant MRI-visible scaffolds for tissue engineering applications.BioImpacts : BI · 2016Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 1 country.
Funding
Abstract
Biomaterials are extensively used to restore damaged tissues, in the forms of implants (e.g. tissue engineered scaffolds) or biomedical devices (e.g. pacemakers). Once in contact with the physiological environment, nanostructured biomaterials undergo modifications as a result of endogenous proteins binding to their surface. The formation of this macromolecular coating complex, known as 'protein corona', onto the surface of nanoparticles and its effect on cell-particle interactions are currently under intense investigation. In striking contrast, protein corona constructs within nanostructured porous tissue engineering scaffolds remain poorly characterized. As organismal systems are highly dynamic, it is conceivable that the formation of distinct protein corona on implanted scaffolds might itself modulate cell-extracellular matrix interactions. Here, we report that corona complexes formed onto the fibrils of engineered collagen scaffolds display specific, distinct, and reproducible compositions that are a signature of the tissue microenvironment as well as being indicative of the subject's health condition. Protein corona formed on collagen matrices modulated cellular secretome in a context-specific manner
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.