ArticleJournal of applied physiology (Bethesda, Md. : 1985)2016
FloWave.US: validated, open-source, and flexible software for ultrasound blood flow analysis.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed.
- Exercise training improves vascular function in patients with Alzheimer's disease.European journal of applied physiology · 2020Trial
- Lower limb blood flow responses during higher- and lower-load bilateral leg press exercise.Experimental physiology · 2026Article
- Macro- and microcirculatory factors affecting foot temperature change during walking.Experimental physiology · 2026Article
- Increased symptomatic autonomic dysfunction is associated with greater cardiovascular endothelial dysfunction following spinal cord injury.PM & R : the journal of injury, function, and rehabilitation · 2026Article
- The influence of aging on graded peripheral venous return and complex blood flow features through human veins.GeroScience · 2026Article
- Influence of hydrostatic gradients and diurnal rhythm on cerebral and ocular blood flow.European journal of applied physiology · 2026Article
- Optimizing the predictive validity of NIRS kinetic profiles to predict aerobic capacity from a resting skeletal muscle occlusion test.Experimental physiology · 2026Article
- Interaction of sublingual glyceryl tri-nitrate administration on single muscle contraction-induced hyperemia: potential insight into the role of the skeletal muscle pump.Frontiers in physiology · 2026Article
- Cardiorespiratory and vascular function outcomes following 4 weeks of single-sprint training.Frontiers in physiology · 2026Article
- A Doppler Ultrasound Method to Measure Vascular Responses to Walking.bioRxiv : the preprint server for biology · 2025Article
- Effects of repeated sprint exercise on brachial artery shear rate patterns in healthy adults.Physiological reports · 2025Article
- Measurement of pressure dependent variations in local pulse wave velocity within a cardiac cycle from forward travelling pulse waves.Scientific reports · 2025Article
- Enhancing flow-mediated dilation analysis by optimizing an open-source software with automated edge detection.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- Article
- The impact of leg position on muscle blood flow and oxygenation during low-intensity rhythmic plantarflexion exercise.European journal of applied physiology · 2023Article
- Associations between Endothelial Lipase, High-Density Lipoprotein, and Endothelial Function Differ in Healthy Volunteers and Metabolic Syndrome Patients.International journal of molecular sciences · 2023Article
- The effects of a firefighting simulation on the vascular and autonomic functions and cognitive performance: a randomized crossover study.Frontiers in physiology · 2023Article
- Control of blood pressure in the cold: differentiation of skin and skeletal muscle vascular resistance.Experimental physiology · 2023Article
- Seven days of ischemic preconditioning augments hypoxic exercise ventilation and muscle oxygenation in recreationally trained males.American journal of physiology. Regulatory, integrative and comparative physiology · 2022Article
- Effects of exercise modalities on decreased blood pressure in patients with hypertension.Frontiers in physiology · 2022Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Automated software improves the accuracy and reliability of blood velocity, vessel diameter, blood flow, and shear rate ultrasound measurements, but existing software offers limited flexibility to customize and validate analyses. We developed FloWave.US-open-source software to automate ultrasound blood flow analysis-and demonstrated the validity of its blood velocity (aggregate relative error, 4.32%) and vessel diameter (0.31%) measures with a skeletal muscle ultrasound flow phantom. Compared with a commercial, manual analysis software program, FloWave.US produced equivalent in vivo cardiac cycle time-averaged mean (TAMean) velocities at rest and following a 10-s muscle contraction (mean bias <1 pixel for both conditions). Automated analysis of ultrasound blood flow data was 9.8 times faster than the manual method. Finally, a case study of a lower extremity muscle contraction experiment highlighted the ability of FloWave.US to measure small fluctuations in TAMean velocity, vessel diameter, and mean blood flow at specific time points in the cardiac cycle. In summary, the collective features of our newly designed software-accuracy, reliability, reduced processing time, cost-effectiveness, and flexibility-offer advantages over existing proprietary options. Further, public distribution of FloWave.US allows researchers to easily access and customize code to adapt ultrasound blood flow analysis to a variety of vascular physiology applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.