ArticleThe Journal of antimicrobial chemotherapy2016
Universal hospital admission screening for carbapenemase-producing organisms in a low-prevalence setting.
Article in The Journal of antimicrobial chemotherapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Screening for carbapenemase-producing Enterobacterales (CPE)-considering the practical implications of molecular results, the value of culture and deciding criteria for resistance.The Journal of antimicrobial chemotherapy · 2025Article
- Model-based evaluation of admission screening strategies for the detection and control of carbapenemase-producing Enterobacterales in the English hospital setting.BMC medicine · 2023Article
- Investigating Resistance to Carbapenems in Enterobacterales: A Descriptive Epidemiological Study of 2021 Screening in an Italian Teaching Hospital.Pathogens (Basel, Switzerland) · 2023Article
- Hospital-Acquired Infections Caused by Carbapenem-Resistant Enterobacteriaceae: An Observational Study.Microorganisms · 2023Article
- Article
- Cost-effectiveness of strategies to control the spread of carbapenemase-producing Enterobacterales in hospitals: a modelling study.Antimicrobial resistance and infection control · 2022Article
- Epidemiology and Transmission of Carbapenemase-ProducingAntimicrobial agents and chemotherapy · 2021Article
- Population-level faecal metagenomic profiling as a tool to predict antimicrobial resistance inEClinicalMedicine · 2021Article
- What are acute NHS trusts in England doing to prevent the cross-border spread of carbapenem-resistant Enterobacteriaceae?Journal of infection prevention · 2020Article
- Evaluation of Xpert Carba-R Assay v.2 to Detect Carbapenemase Genes in Two Hospitals in Korea.Annals of laboratory medicine · 2020Article
- Article
- Epidemiological, clinical, and microbiological characteristics of carbapenemase-producing Enterobacteriaceae bloodstream infection in the Republic of Korea.Antimicrobial resistance and infection control · 2019Article
- Fast and expensive (PCR) or cheap and slow (culture)? A mathematical modelling study to explore screening for carbapenem resistance in UK hospitals.BMC medicine · 2018Article
- Incidence of infections due to third generation cephalosporin-resistantAntimicrobial resistance and infection control · 2018Observational
- Audit of the management of patients at high risk of carbapenemase-producing enterobacteriaceae (CPE): Are we ready?Journal of infection prevention · 2017Article
- A Decade of Development of Chromogenic Culture Media for Clinical Microbiology in an Era of Molecular Diagnostics.Clinical microbiology reviews · 2017Review
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCarbapenemase-producing Enterobacteriaceae (CPE) are an emerging threat for healthcare providers worldwide.
objectivesTo determine CPE carriage rates and risk factors in an unselected hospital cohort at the time of admission.
methodsWe approached 4567 patients within 72 h of admission to provide a rectal swab and answer a questionnaire on risk factors for carriage. Rectal swabs were cultured for carbapenem-resistant organisms on chromogenic and non-chromogenic agar, and tested for carbapenemase production by PCR (Check-Direct CPE). The study was approved by the NHS Research Ethics Committee.
resultsOnly 6 CPE were cultured from 5 (0.1%) of 4006 patients who provided a rectal swab; only 1 was cultured using non-chromogenic media. An additional 76 culture-negative rectal swabs were initially PCR positive, but none grew a carbapenem-resistant organism despite enrichment culture and only two were positive when retested several months later by Check-Direct and a second PCR assay (Cepheid GeneXpert
conclusionsThis study highlights a very low carriage rate of CPE. Hospitalization abroad is the most important risk factor to guide admission screening in this low-prevalence setting.
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