Evidence map›Paper›PMID 27516447›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2017

Dual-Modality Imaging of Prostate Cancer with a Fluorescent and Radiogallium-Labeled Gastrin-Releasing Peptide Receptor Antagonist.

Hanwen Zhang, Pooja Desai, Yusuke Koike, Jacob Houghton, Sean Carlin, Nidhi Tandon, Karim Touijer, Wolfgang A Weber

Open access · bronzeAbstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 47 citations in OpenAlex.

  1. Value ofEuropean radiology · 2023
    Trial
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. A Dual-Modality Linker Enables Site-Specific Conjugation of Antibody Fragments forJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2019
    Article
  16. Article
  17. Article
  18. New Developments in Dual-Labeled Molecular Imaging Agents.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2019
    Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Hanwen ZhangDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.
Pooja DesaiDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.
Yusuke KoikeDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.
Jacob HoughtonDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.
Sean CarlinDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.
Nidhi TandonDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.
Karim TouijerDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York; and.
Wolfgang A WeberDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York weberw@mskcc.org.
Memorial Sloan Kettering Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

Gastrin-releasing peptide (GRP) receptors (GRPr) are frequently overexpressed in human prostate cancer, and radiolabeled GRPr affinity ligands have shown promise for in vivo imaging of prostate cancer with PET. The goal of this study was to develop a dual-modality imaging probe that can be used for noninvasive PET imaging and optical imaging of prostate cancer.

methodsWe designed and synthesized an IRDye 650 and DOTA-conjugated GRPr antagonist, HZ220 (DOTA-Lys(IRDye 650)-PEG

resultsAfter hydrophilic-lipophilic balance cartridge purification,

conclusion

Indexed as

AnimalsBiomarkers, TumorCell Line, TumorGallium RadioisotopesHumansIsotope LabelingMaleMetabolic Clearance RateMiceMice, NudeMicroscopy, FluorescenceMolecular ImagingMultimodal ImagingOrgan SpecificityPositron-Emission TomographyProstatic NeoplasmsBiomarkers, TumorGallium RadioisotopesRadiopharmaceuticalsReceptors, Bombesinbombesin antagonistGRP receptoroptical imagingPET imagingprostate cancer

Identifiers

PMID27516447
PMCPMC5209642
OpenAlexW2510815041

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.