ArticleCarbohydrate polymers2016
Injectable and microporous scaffold of densely-packed, growth factor-encapsulating chitosan microgels.
Article in Carbohydrate polymers, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Development of a Water-in-Oil Microemulsion Template for Chitosan Nanogel Fabrication via Genipin Crosslinking.Polymers · 2026Article
- Practical Guide to the Design of Granular Hydrogels for Customizing Complex Cellular Microenvironments.Advanced healthcare materials · 2025Review
- Spectroscopic Investigation of Hydrogels Formed from Phenylalanine.Journal of fluorescence · 2025Article
- Sustained Release Studies of Metformin Hydrochloride Drug Using Conducting Polymer/Gelatin-Based Composite Hydrogels.ACS omega · 2024Article
- Recent developments in chitosan based microgels and their hybrids.International journal of biological macromolecules · 2024Review
- Article
- Single versus dual microgel species for forming guest-host microporous annealed particle PEG-MAL hydrogel.Journal of biomedical materials research. Part A · 2023Article
- Covalent Conjugates of Allylbenzenes and Terpenoids as Antibiotics Enhancers with the Function of Prolonged Action.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Fluorescent Probes with Förster Resonance Energy Transfer Function for Monitoring the Gelation and Formation of Nanoparticles Based on Chitosan Copolymers.Journal of functional biomaterials · 2023Article
- Article
- Harnessing decellularised extracellular matrix microgels into modular bioinks for extrusion-based bioprinting with good printability and high post-printing cell viability.Biomaterials translational · 2023Article
- Sticking Together: Injectable Granular Hydrogels with Increased Functionality via Dynamic Covalent Inter-Particle Crosslinking.Small (Weinheim an der Bergstrasse, Germany) · 2022Article
- Fragmenting Bulk Hydrogels and Processing into Granular Hydrogels for Biomedical Applications.Journal of visualized experiments : JoVE · 2022Article
- Review
- Designing robust chitosan-based hydrogels for stem cell nesting under oxidative stress.BioImpacts : BI · 2022Article
- Emulsion-free chitosan-genipin microgels for growth plate cartilage regeneration.Journal of biomaterials applications · 2021Article
- Microfluidics generation of chitosan microgels containing glycerylphytate crosslinker for in situ human mesenchymal stem cells encapsulation.Materials science & engineering. C, Materials for biological applications · 2021Article
- Designing Microgels for Cell Culture and Controlled Assembly of Tissue Microenvironments.Advanced functional materials · 2020Article
- Microgels: Modular, tunable constructs for tissue regeneration.Acta biomaterialia · 2019Review
- Jammed Microgel Inks for 3D Printing Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2019Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
In this work, an emulsion crosslinking method was developed to produce chitosan-genipin microgels which acted as an injectable and microporous scaffold. Chitosan was characterized with respect to pH by light scattering and aqueous titration. Microgels were characterized with swelling, light scattering, and rheometry of densely-packed microgel solutions. The results suggest that as chitosan becomes increasingly deprotonated above the pKa, repulsive forces diminish and intermolecular attractions cause pH-responsive chain aggregation; leading to microgel-microgel aggregation as well. The microgels with the most chitosan and least cross-linker showed the highest yield stress and a storage modulus of 16kPa when condensed as a microgel paste at pH 7.4. Two oppositely-charged growth factors could be encapsulated into the microgels and endothelial cells were able to proliferate into the 3D microgel scaffold. This work motivates further research on the applications of the chitosan microgel scaffold as an injectable and microporous scaffold in regenerative medicine.
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