ArticleJournal of the American Society of Nephrology : JASN2017
BP Control and Long-Term Risk of ESRD and Mortality.
Article in Journal of the American Society of Nephrology : JASN, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association of Intensive Blood Pressure Control and Kidney Disease Progression in Nondiabetic Patients With Chronic Kidney Disease: A Systematic Review and Meta-analysis.JAMA internal medicine · 2017Pooled it
- Association of blood pressure and renal outcome in patients with chronic kidney disease; a post hoc analysis of FROM-J study.Scientific reports · 2021Trial
- Implications of Early Decline in eGFR due to Intensive BP Control for Cardiovascular Outcomes in SPRINT.Journal of the American Society of Nephrology : JASN · 2019Trial
- Acute Declines in Renal Function during Intensive BP Lowering and Long-Term Risk of Death.Journal of the American Society of Nephrology : JASN · 2018Trial
- Empagliflozin protected kidney function in CKD rat through suppressing hypoxic and fibrotic signalings mediated inflammation and EMT.Histology and histopathology · 2026Article
- Blood Pressure and Mortality in Mexico City: A Mendelian Randomization Study.Hypertension (Dallas, Tex. : 1979) · 2025Article
- Impact of intensive blood pressure control on kidney outcomes.Current opinion in nephrology and hypertension · 2025Review
- Association of systolic blood pressure with incident chronic kidney disease estimated by marginal structural model: a nationwide population-based study.Kidney research and clinical practice · 2025Article
- Management of hypertension in chronic kidney disease: current perspectives and therapeutic strategies.Frontiers in medicine · 2025Review
- Effect of Dual RAAS Blockade and Intensive BP Lowering on Risk of End-Stage Kidney Disease and Death in Autosomal Dominant Polycystic Kidney Disease: Long-term Follow-up of the HALT-PKD Trials.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2025Article
- The Legacy Effect of Intensive versus Standard BP Control on the Incidence of Needing Dialysis or Kidney Transplantation.Journal of the American Society of Nephrology : JASN · 2024Article
- Associations With Baseline Blood Pressure Control in NURTuRE-CKD.Kidney international reports · 2024Article
- STING/ACSL4 axis-dependent ferroptosis and inflammation promote hypertension-associated chronic kidney disease.Molecular therapy : the journal of the American Society of Gene Therapy · 2023Article
- The association of BP with cardiovascular outcomes in patients with dipstick proteinuria and preserved kidney function.Hypertension research : official journal of the Japanese Society of Hypertension · 2023Article
- Review
- Chronic Kidney Disease Progression Risk in Patients With Diabetes Mellitus Using Dihydropyridine Calcium Channel Blockers: A Nationwide, Population-Based, Propensity Score Matching Cohort Study.Frontiers in pharmacology · 2022Article
- Hypertension Management in Patients with Chronic Kidney Disease in the Post-SPRINT Era.Electrolyte & blood pressure : E & BP · 2021Review
- SPRINT-A Kidney-Centric Narrative Review: Recent Advances in Hypertension.Hypertension (Dallas, Tex. : 1979) · 2021Review
- Brazilian Guidelines of Hypertension - 2020.Arquivos brasileiros de cardiologia · 2021Article
- Factors Associated With Failure to Achieve the Intensive Blood Pressure Target in the Systolic Blood Pressure Intervention Trial (SPRINT).Hypertension (Dallas, Tex. : 1979) · 2020Article
Corrections and comments
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Authors and funding
23 authors.
Funding
Abstract
We recently showed an association between strict BP control and lower mortality risk during two decades of follow-up of prior participants in the Modification of Diet in Renal Disease (MDRD) trial. Here, we determined the risk of ESRD and mortality during extended follow-up of the African American Study of Kidney Disease and Hypertension (AASK) trial. We linked 1067 former AASK participants with CKD previously randomized to strict or usual BP control (mean arterial pressure ≤92 mmHg or 102-107 mmHg, respectively) to the US Renal Data System and Social Security Death Index; 397 patients had ESRD and 475 deaths occurred during a median follow-up of 14.4 years from 1995 to 2012. Compared with the usual BP arm, the strict BP arm had unadjusted and adjusted relative risks of ESRD of 0.92 (95% confidence interval [95% CI], 0.75 to 1.12) and 0.95 (95% CI, 0.78 to 1.16; P=0.64), respectively, and unadjusted and adjusted relative risks of death of 0.92 (95% CI, 0.77 to 1.10) and 0.81 (95% CI, 0.68 to 0.98; P=0.03), respectively. In meta-analyses of individual-level data from the MDRD and the AASK trials, unadjusted relative risk of ESRD was 0.88 (95% CI, 0.78 to 1.00) and unadjusted relative risk of death was 0.87 (95% CI, 0.76 to 0.99) for strict versus usual BP arms. Our findings suggest that, during long-term follow-up, strict BP control does not delay the onset of ESRD but may reduce the relative risk of death in CKD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.