Evidence map›Paper›PMID 27515947›Full record

ArticleBMC neurology2016

Cerebral vasospasm and wernicke encephalopathy secondary to adult cyclic vomiting syndrome: the role of magnesium.

Álvaro Sánchez-Larsen, Tomás Segura, Susana García-Muñozguren, Javier Peinado-Ródenas, Joaquín Zamarro, Francisco Hernández-Fernández

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Álvaro Sánchez-LarsenDepartment of Neurology, Complejo Hospitalario Universitario de Albacete, Albacete, Spain. aa.sanchezlarsen@gmail.com.ORCID http://orcid.org/0000-0003-2134-4980
Tomás SeguraDepartment of Neurology, Complejo Hospitalario Universitario de Albacete, Albacete, Spain.
Susana García-MuñozgurenDepartment of Neurology, Grupo Hospitales de Madrid, Madrid, Spain.
Javier Peinado-RódenasDepartment of Radiology, Complejo Hospitalario Universitario de Albacete, Albacete, Spain.
Joaquín ZamarroUnit of Interventional Neuroradiology, Department of Radiology, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain.
Francisco Hernández-FernándezDepartment of Neurology, Complejo Hospitalario Universitario de Albacete, Albacete, Spain.
Complejo Hospitalario Universitario de Albacete · ESHospital Universitario Virgen de la Arrixaca · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMagnesium has a regulatory role in the excitability of cell membranes, and is also a cofactor in the phosphorylation of thiamine. Hypomagnesemia has been associated with coronary vasospasm, but its role in cerebrovascular pathology is controversial, and cerebral vasospasm exclusively attributable to hypomagnesemia has not been reported in humans. CASE PRESENTATION: We report the case of a 51-year-old man in whom uncontrollable vomiting, treatment with omeprazole and thiazide, and renal impairment lead to a severe hypomagnesemia (magnesium below the level of detection in blood tests), which secondarily caused Wernicke's encephalopathy and vasospasm in multiple cerebral arteries (seen with cerebral angiography and CT angiography) that presented with a complete right hemisphere neurological deficit. These disturbances completely resolved when magnesium levels were normalized and subsequent neuroimaging tests confirmed the resolution of angiographic changes.

conclusionOur case suggests that hypomagnesemia should be considered in the differential diagnosis of patients with neurological symptoms and predisposing causes.

Indexed as

Diagnosis, DifferentialHumansKidney DiseasesMagnesiumMaleMiddle AgedOmeprazoleProton Pump InhibitorsThiazidesVasospasm, IntracranialVomitingWernicke EncephalopathyMagnesiumOmeprazoleProton Pump InhibitorsThiazidesCase reportCerebral vasospasmCyclic vomiting syndromeHypomagnesemiaWernicke encephalopathy

Identifiers

PMID27515947
PMCPMC4982311
OpenAlexW2516879352

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.