ArticleBMC neurology2016
Intrathecal synthesis of anti-Hu antibodies distinguishes patients with paraneoplastic peripheral neuropathy and encephalitis.
Article in BMC neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- What is the significance of onconeural antibodies for psychiatric symptomatology? A systematic review.BMC psychiatry · 2017Pooled it
- Identification of DAGLA as an autoantibody target in cerebellar ataxia.Journal of neurology, neurosurgery, and psychiatry · 2024Article
- Clinical and paraclinical characteristics of optic neuritis in the context of the McDonald criteria 2017.Scientific reports · 2024Article
- Autoantibodies in neuromuscular disorders: a review of their utility in clinical practice.Frontiers in neurology · 2024Review
- Anti-GABAB receptor encephalitis: clinical and laboratory characteristics, imaging, treatments and prognosis.Frontiers in immunology · 2024Article
- Anti-adenylate kinase 5 encephalitis: Clinical characteristics, diagnosis, and management of this rare entity.Journal of translational autoimmunity · 2023Review
- Revisiting anti-Hu paraneoplastic autoimmunity: phenotypic characterization and cancer diagnosis.Brain communications · 2023Article
- Diagnosis and Clinical Features in Autoimmune-Mediated Movement Disorders.Journal of movement disorders · 2022Article
- CIDP associated with Sjögren's syndrome.Journal of neurology · 2021Article
- CRMP5 Antibodies-Diagnostic Challenges.Frontiers in neurology · 2021Article
- Paraneoplastic Neuropathies: What's New Since the 2004 Recommended Diagnostic Criteria.Frontiers in neurology · 2021Review
- Evidence of Oligoclonal Bands Does Not Exclude Non-Inflammatory Neurological Diseases.Diagnostics (Basel, Switzerland) · 2020Article
- Autoantibody-associated psychiatric symptoms and syndromes in adults: A narrative review and proposed diagnostic approach.Brain, behavior, & immunity - health · 2020Article
- Alemtuzumab therapy changes immunoglobulin levels in peripheral blood and CSF.Neurology(R) neuroimmunology & neuroinflammation · 2020Article
- Diagnosis and Differential Diagnosis of Neurological Adverse Events during Immune Checkpoint Inhibitor Therapy.Journal of oncology · 2020Article
- Varicella zoster virus infections in neurological patients: a clinical study.BMC infectious diseases · 2018Article
- Elevated LGI1-IgG CSF index predicts worse neurological outcome.Annals of clinical and translational neurology · 2018Article
- Clinically Isolated Syndrome According to McDonald 2010: Intrathecal IgG Synthesis Still Predictive for Conversion to Multiple Sclerosis.International journal of molecular sciences · 2017Article
- Common and uncommon neurological manifestations of neuroborreliosis leading to hospitalization.BMC infectious diseases · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundParaneoplastic syndromes are serious immune caused diseases of the peripheral and/or central nervous system associated with malignant neoplasm. Symptoms develop when antibodies against antigens expressed by tumor cells cross-react with neuronal proteins. Antineuronal antibodies are usually examined in patient's sera while examination of the cerebrospinal fluid (CSF) often fails. Furthermore, the few previous reports describing CSF data summarized different antineuronal antibodies and/or regarded patients with different neurological symptoms as one group.
methodsWe retrospectively evaluated data of 18 patients with paraneoplastic syndromes due to anti-Hu antibodies. The study aimed to differentiate patients with peripheral neuropathy and encephalitis by cerebrospinal fluid (CSF) parameters including anti-Hu antibody titers.
resultsOur results confirm previous observations that serum titers of anti-Hu antibodies and standard CSF values do not differ between patients with neuropathy and encephalitis. However, analysis of CSF anti-Hu titers and calculating the intrathecal synthesis helped to discriminate between both groups.
conclusionIn conclusion, our results indicate that patients even with one defined antineuronal antibody need to be regarded separately depending on the involved location of the nervous system. We recommend incorporation of anti-Hu analyses in the CSF and calculating the intrathecal synthesis in patients with anti-Hu syndrome.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.