ArticleBMJ open2016
Does pre-pregnancy BMI determine blood pressure during pregnancy? A prospective cohort study.
Article in BMJ open, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
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Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Effects of maternal education on maternal and perinatal outcomes: An individual participant data meta-analysis of 2 356 402 pregnancies.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026Pooled it
- Development and validation of prediction models for fetal growth restriction and birthweight: an individual participant data meta-analysis.Health technology assessment (Winchester, England) · 2024Pooled it
- Late-pregnancy air pollution exposure and neonatal anthropometry with and without gestational hypertension.iScience · 2026Article
- Blood pressure in the second and third trimesters of pregnancy and adverse pregnancy outcomes in singleton pregnancies: A bidirectional cohort study.European journal of obstetrics & gynecology and reproductive biology: X · 2025Article
- Effects of pre-pregnancy BMI and gestational weight gain on pregnancy and neonatal outcomes in Poland.Scientific reports · 2025Article
- Pathophysiology of Maternal Obesity and Hypertension in Pregnancy.Journal of cardiovascular development and disease · 2025Review
- Article
- Association between maternal cardiometabolic markers and fetal growth in non-complicated pregnancies: a secondary analysis of the PRINCESA cohort.Scientific reports · 2024Article
- Article
- Pregnancy-associated changes in urinary uromodulin excretion in chronic hypertension.Journal of nephrology · 2024Article
- Maternal pre-pregnancy obesity affects the uncinate fasciculus white matter tract in preterm infants.Frontiers in pediatrics · 2023Article
- Pre-pregnancy body mass index and glycated-hemoglobin with the risk of metabolic diseases in gestational diabetes: a prospective cohort study.Frontiers in endocrinology · 2023Article
- Efficacy of magnesium sulfate combined with nifedipine for pregnancy-induced hypertension syndrome and its relation to glucose and lipid metabolism.American journal of translational research · 2023Article
- A prospective study of arsenic and manganese exposures and maternal blood pressure during gestation.Environmental research · 2022Article
- Is new onset hypertension in obese women more likely to be Gestational Hypertension? - A retrospective study.Journal of family medicine and primary care · 2022Article
- Inconsistency in prevalence of hypertension based on self-reports and use of standard tests: Implications for large scale surveys.SSM - population health · 2022Article
- Obstetric outcomes during delivery hospitalizations among obese pregnant women in the United States.Scientific reports · 2022Article
- High prevalence of obstructive sleep apnea in pregnant women with class III obesity: a prospective cohort study.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022Article
- Prediction of pre-eclampsia complicated by fetal growth restriction and its perinatal outcome based on an artificial neural network model.Frontiers in physiology · 2022Article
- Association of pre-pregnancy body mass index and rate of weight gain during pregnancy with maternal indicators of cardiometabolic risk.Nutrition & diabetes · 2021Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo evaluate if pre-pregnancy body mass index (BMI) determines blood pressure throughout pregnancy and to explore the role of gestational weight gain in this association. In addition, the effects of pre-pregnancy BMI and gestational weight gain on the occurrence of gestational hypertension and pre-eclampsia were investigated.
designProspective cohort study.
settingMaternal and child health primary care referral centre, Jakarta, Indonesia. POPULATION AND MEASUREMENTS: 2252 pregnant women visiting Budi Kemuliaan Hospital and its branch for regular antenatal care visits from July 2012 to April 2015. Pre-pregnancy BMI (kg/m(2)) was based on self-reported pre-pregnancy weight and measured height at first visit. Gestational weight gain was calculated as weight at the day of delivery minus the pre-pregnancy weight. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) were measured during pregnancy at every visit. Linear mixed models were used to analyse this relation with repeated blood pressure measures as the outcome and pre-pregnancy BMI as the predictor. When looking at gestational hypertension and pre-eclampsia as outcomes, (multiple) logistic regression was used in the analysis.
resultsIndependent of pre-pregnancy BMI, SBP and DBP increased by 0.99 mm Hg/month and 0.46 mm Hg/month, respectively. Higher pre-pregnancy BMI was associated with higher pregnancy SBP (0.25 mm Hg/kg/m(2); 95% CI 0.17 to 0.34; p<0.01) and DBP (0.18 mm Hg/kg/m(2); 0.13 to 0.24; p<0.01) in adjusted analysis. Every 1 kg/m(2) higher pre-pregnancy BMI was associated with 6% and 9% higher odds for gestational hypertension (adjusted OR (aOR) 1.06; 95% CI 1.03 to 1.09; p<0.01) and pre-eclampsia (aOR 1.09; 1.04 to 1.14; p<0.01). Accounting for gestational weight gain did not attenuate these associations.
conclusionsPre-pregnancy BMI determines the level, but not the change, of blood pressure in pregnancy and is linked to higher odds for gestational hypertension and pre-eclampsia, independent of gestational weight gain.
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