Evidence map›Paper›PMID 27515723›Full record

ArticleDrug and alcohol dependence2016

Cue-elicited increases in incentive salience for marijuana: Craving, demand, and attentional bias.

Jane Metrik, Elizabeth R Aston, Christopher W Kahler, Damaris J Rohsenow, John E McGeary, Valerie S Knopik, James MacKillop

Abstract read
In one paragraph

Article in Drug and alcohol dependence, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Gimmie the Gummies: Initial validation of the Edibles Marijuana Purchase Task.Experimental and clinical psychopharmacology · 2026
    Article
  5. Article
  6. Artificial Intelligence Approximates Human Affect Ratings of Cannabis Images.medRxiv : the preprint server for health sciences · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Cannabis demand and use among veterans: A prospective examination.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2023
    Article
  16. Reliability of an adaptive marijuana purchase task.Experimental and clinical psychopharmacology · 2023
    Article
  17. Article
  18. Article
  19. Review
  20. Positive Affect: Nature and brain bases of liking and wanting.Current opinion in behavioral sciences · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jane MetrikCenter for Alcohol and Addiction Studies, Brown University School of Public Health, Providence, RI, 02903, USA; Providence Veterans Affairs Medical Center, Providence, RI, 02908, USA. Electronic address: Jane_Metrik@Brown.edu.
Elizabeth R AstonCenter for Alcohol and Addiction Studies, Brown University School of Public Health, Providence, RI, 02903, USA.
Christopher W KahlerCenter for Alcohol and Addiction Studies, Brown University School of Public Health, Providence, RI, 02903, USA.
Damaris J RohsenowCenter for Alcohol and Addiction Studies, Brown University School of Public Health, Providence, RI, 02903, USA; Providence Veterans Affairs Medical Center, Providence, RI, 02908, USA.
John E McGearyProvidence Veterans Affairs Medical Center, Providence, RI, 02908, USA; Rhode Island Hospital, Alpert Medical School of Brown University, Providence, RI, 02903, USA.
Valerie S KnopikRhode Island Hospital, Alpert Medical School of Brown University, Providence, RI, 02903, USA.
James MacKillopDepartment of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, L8N 3K7 Canada.

Funding

Behavioral Economic Analysis of Demand for MarijuanaK01DA039311 · NIDA · BROWN UNIVERSITY · PI ASTON, ELIZABETH · 2015 to 2019
$902k
Enhancing Alcoholism Pharmacotherapy Research via Behavioral EconomicsK23AA016936 · NIAAA · UNIVERSITY OF GEORGIA · PI MACKILLOP, JAMES · 2008 to 2012
$805k
Genetic variation and marijuana's pharmacologic and cue-elicted effectsR03DA027484 · NIDA · BROWN UNIVERSITY · PI KNOPIK, VALERIE S, METRIK, JANE · 2009 to 2010
$483k
NIAAA NIH HHS K23 AA016936NIDA NIH HHS K01 DA039311NIDA NIH HHS R03 DA027484
6 · The paper itself

Abstract

backgroundIncentive salience is a multidimensional construct that includes craving, drug value relative to other reinforcers, and implicit motivation such as attentional bias to drug cues. Laboratory cue reactivity (CR) paradigms have been used to evaluate marijuana incentive salience with measures of craving, but not with behavioral economic measures of marijuana demand or implicit attentional processing tasks.

methodsThis within-subjects study used a new CR paradigm to examine multiple dimensions of marijuana's incentive salience and to compare CR-induced increases in craving and demand. Frequent marijuana users (N=93, 34% female) underwent exposure to neutral cues then to lit marijuana cigarettes. Craving, marijuana demand via a marijuana purchase task, and heart rate were assessed after each cue set. A modified Stroop task with cannabis and control words was completed after the marijuana cues as a measure of attentional bias.

resultsRelative to neutral cues, marijuana cues significantly increased subjective craving and demand indices of intensity (i.e., drug consumed at $0) and Omax (i.e., peak drug expenditure). Elasticity significantly decreased following marijuana cues, reflecting sustained purchase despite price increases. Craving was correlated with demand indices (r's: 0.23-0.30). Marijuana users displayed significant attentional bias for cannabis-related words after marijuana cues. Cue-elicited increases in intensity were associated with greater attentional bias for marijuana words.

conclusionsGreater incentive salience indexed by subjective, behavioral economic, and implicit measures was observed after marijuana versus neutral cues, supporting multidimensional assessment. The study highlights the utility of a behavioral economic approach in detecting cue-elicited changes in marijuana incentive salience.

Indexed as

Attentional BiasCravingCuesAdolescentAdultCannabisCommerceEconomics, BehavioralFemaleHeart RateHumansMaleMarijuana AbuseMarijuana SmokingMotivationYoung AdultAttentional biasBehavioral economicsCue reactivityIncentive salienceMarijuana

Identifiers

PMID27515723
PMCPMC5037029

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.