Evidence map›Paper›PMID 27515368›Full record

ArticleAnnals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc2017

Frontal QRS-T Angle and the Risk of Atrial Fibrillation in the Elderly.

Hanumantha R Jogu, Wesley T O'Neal, Stephen T Broughton, Amit J Shah, Zhu-Ming Zhang, Elsayed Z Soliman

Abstract read
In one paragraph

Article in Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Electrocardiographic Predictors of Atrial Fibrillation.Medical sciences (Basel, Switzerland) · 2023
    Pooled it
  2. Article
  3. Article
  4. Observational
  5. Article
  6. Article
  7. Electrocardiographic markers of subclinical atrial fibrillation detected by implantable loop recorder: insights from the LOOP Study.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023
    Article
  8. The Relationship between the Frontal QRS-T Angle on ECG and Physical Activity Level in Young Adults.International journal of environmental research and public health · 2023
    Article
  9. Article
  10. Article
  11. Atrial Fibrillation in Long QT Syndrome by Genotype.Circulation. Arrhythmia and electrophysiology · 2019
    Article
  12. The role of baseline and post-procedural frontal plane QRS-T angles for cardiac risk assessment in patients with acute STEMI.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2018
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Hanumantha R JoguDepartment of Hospital Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Wesley T O'NealDepartment of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Stephen T BroughtonDepartment of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Amit J ShahDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Zhu-Ming ZhangDepartment of Public Health Sciences, Epidemiological Cardiology Research Center, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Elsayed Z SolimanDepartment of Public Health Sciences, Epidemiological Cardiology Research Center, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Wake Forest University · USEmory University · US

Funding

Atlanta Clinical and Translational Science Institute (ACTSI) RenewalUL1TR000454 · NCATS · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2012 to 2016
$25.8M
Emotional Stress as a Risk Factor for Arrhythmia: Ischemic and Genetic MechanismsK23HL127251 · NHLBI · EMORY UNIVERSITY · PI SHAH, AMIT JASVANT · 2016 to 2019
$749k
NCATS NIH HHS UL1 TR000454NHLBI NIH HHS K23 HL127251
6 · The paper itself

Abstract

backgroundFrontal QRS-T angle reflects changes in regional action potential duration and the direction of repolarization. Although it has been suggested that abnormal ventricular repolarization predisposes to atrial arrhythmias, it is unknown whether abnormal frontal QRS-T angle is associated with an increased risk of atrial fibrillation (AF).

methodsWe examined the association between frontal QRS-T angle and AF in 4282 participants (95% white; 41% male) from the Cardiovascular Health Study (CHS). QRS-T angle was computed from baseline electrocardiogram data. Abnormal QRS-T angle was defined as values greater than the sex-specific 95th percentile (men >131°; women: >104°). AF cases were identified from study electrocardiograms and from hospitalization discharge data through December 31, 2010. Cox regression was used to compute hazard ratios (HR) and 95% confidence intervals (CI) for the association between abnormal QRS-T angle and AF.

resultsOver a median follow-up of 12.1 years, a total of 1276 (30%) participants developed AF. In a Cox regression model, adjusted for socio-demographics and known AF risk factors, abnormal QRS-T angle was associated with a 55% increased risk of AF (HR = 1.55, 95%CI = 1.23, 1.97). When QRS-T angle was examined as a continuous variable, each 10° increase was associated with a 3% increased risk of AF (HR = 1.03, 95%CI = 1.01, 1.05). This finding was consistent in subgroups stratified by age, sex, and race.

conclusionOur findings suggest that an abnormal frontal QRS-T angle on the electrocardiogram provides important prognostic information regarding AF risk in the elderly, and further implicate ventricular repolarization abnormalities in the pathogenesis of AF.

Indexed as

AgedAged, 80 and overAtrial FibrillationCohort StudiesElectrocardiographyFemaleFollow-Up StudiesHeart Conduction SystemHumansLongitudinal StudiesMalePrognosisProportional Hazards ModelsProspective StudiesRisk AssessmentRisk Factorsatrial fibrillationelectrocardiogramrisk

Identifiers

PMID27515368
PMCPMC5303692
OpenAlexW2512360894

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.