Evidence map›Paper›PMID 27514629›Full record

Trial reportActa neuropsychiatrica2017

A randomised controlled trial of adjunctive yoga and adjunctive physical exercise training for cognitive dysfunction in schizophrenia.

Triptish Bhatia, Sati Mazumdar, Joel Wood, Fanyin He, Raquel E Gur, Ruben C Gur, Vishwajit L Nimgaonkar, Smita N Deshpande

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Acta neuropsychiatrica, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Yoga as part of a package of care versus standard care for schizophrenia.The Cochrane database of systematic reviews · 2017
    Pooled it
  6. Yoga versus non-standard care for schizophrenia.The Cochrane database of systematic reviews · 2017
    Pooled it
  7. Trial
  8. Trial
  9. Trial
  10. Trial
  11. Article
  12. Review
  13. Article
  14. Prescribing Yoga for Mental Wellness: Need for a Nuanced Approach.Indian journal of psychological medicine · 2024
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Aerobic exercise in severe mental illness: requirements from the perspective of sports medicine.European archives of psychiatry and clinical neuroscience · 2022
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Triptish Bhatia1GRIP-NIH Project,Department of Psychiatry,PGIMER-Dr. R.M.L. Hospital,New Delhi,India.
Sati Mazumdar2Department of Biostatistics,University of Pittsburgh,Pittsburgh,PA,USA.
Joel Wood3WPIC,University of Pittsburgh Medical Center,Pittsburgh,PA,USA.
Fanyin He2Department of Biostatistics,University of Pittsburgh,Pittsburgh,PA,USA.
Raquel E Gur4Department of Psychiatry,University of Pennsylvania,Philadelphia,PA,USA.
Ruben C Gur4Department of Psychiatry,University of Pennsylvania,Philadelphia,PA,USA.
Vishwajit L Nimgaonkar5Department of Psychiatry,University of Pittsburgh,Pittsburgh,PA,USA.
Smita N Deshpande7Department of Psychiatry,PGIMER-Dr. R.M.L. Hospital,New Delhi,India.

Funding

NEUROBEHAVIORAL STUDY OF SCHIZOPHRENIAR01MH042191 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI GUR, RAQUEL E · 1987 to 2018
$7.1M
A Neurobehavioral Family Study of SchizophreniaR01MH063480 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NIMGAONKAR, VISHWAJIT LAXMIKANT · 2001 to 2018
$6.1M
Psychiatric research infrastructure for intervention and implementation in India – TEAMSD43TW009114 · FIC · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Smita N Deshpande, Mary Elizabeth Hawk · 2014 to 2026
$3.2M
Tri National Training Program in Psychiatric GeneticsD43TW008302 · FIC · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MANSOUR, HADER A., NIMGAONKAR, VISHWAJIT LAXMIKANT · 2009 to 2013
$542k
The Impact of Yoga Supplementation On Cognitive Function Among Indian OutpatientsR01TW008289 · FIC · DR RAM MANOHAR LOHIA HOSPITAL · PI BHATIA, TRIPTISH · 2010 to 2014
$264k
FIC NIH HHS D43 TW008302FIC NIH HHS D43 TW009114FIC NIH HHS R01 TW008289NIMH NIH HHS R01 MH042191NIMH NIH HHS R01 MH063480
6 · The paper itself

Abstract

backgroundYoga and physical exercise have been used as adjunctive intervention for cognitive dysfunction in schizophrenia (SZ), but controlled comparisons are lacking. Aims A single-blind randomised controlled trial was designed to evaluate whether yoga training or physical exercise training enhance cognitive functions in SZ, based on a prior pilot study.

methodsConsenting, clinically stable, adult outpatients with SZ (n=286) completed baseline assessments and were randomised to treatment as usual (TAU), supervised yoga training with TAU (YT) or supervised physical exercise training with TAU (PE). Based on the pilot study, the primary outcome measure was speed index for the cognitive domain of 'attention' in the Penn computerised neurocognitive battery. Using mixed models and contrasts, cognitive functions at baseline, 21 days (end of training), 3 and 6 months post-training were evaluated with intention-to-treat paradigm.

resultsSpeed index of attention domain in the YT group showed greater improvement than PE at 6 months follow-up (p<0.036, effect size 0.51). In the PE group, 'accuracy index of attention domain showed greater improvement than TAU alone at 6-month follow-up (p<0.025, effect size 0.61). For several other cognitive domains, significant improvements were observed with YT or PE compared with TAU alone (p<0.05, effect sizes 0.30-1.97).

conclusionsBoth YT and PE improved attention and additional cognitive domains well past the training period, supporting our prior reported beneficial effect of YT on speed index of attention domain. As adjuncts, YT or PE can benefit individuals with SZ.

Indexed as

Exercise TherapySchizophrenic PsychologyYogaAdultAttentionCognitive DysfunctionFacial RecognitionFemaleHumansMaleMemory, Short-TermNeuropsychological TestsSchizophreniaSpatial MemoryTreatment Outcomecognitionphysical exerciseRCTschizophreniayoga

Identifiers

PMID27514629
PMCPMC5303681

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.