ArticleBMC microbiology2016
Household air pollution and the lung microbiome of healthy adults in Malawi: a cross-sectional study.
Article in BMC microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.
- Human microbiota research in Africa: a systematic review reveals gaps and priorities for future research.Microbiome · 2021Pooled it
- Effect of Household Air Pollution on the Gut Microbiome and Virome of Adult Women Living in Uganda.Environmental health perspectives · 2026Trial
- Shotgun metagenomic profiling of bacterial microbiomes, metagenome-assembled genomes and antimicrobial resistance in respiratory and blood samples from Gambian children with pneumonia.Research square · 2026Article
- In Vitro Assessment ofGlobal challenges (Hoboken, NJ) · 2025Article
- Heterogeneous impact of fine particulate matter constituents on pulmonary tuberculosis onset: a multicenter time series study in Beijing.BMC public health · 2025Article
- Human Sputum Microbiome Composition and Sputum Inflammatory Cell Profiles Are Altered with Controlled Wood Smoke Exposure as a Model for Wildfire Smoke.American journal of respiratory and critical care medicine · 2025Article
- Fisetin Mitigates Chronic Lung Injury Induced by Benzo(a)Pyrene by Regulation of Inflammation and Oxidative Stress.Current issues in molecular biology · 2025Article
- The microbiome of Total Suspended Particles and its influence on the respiratory microbiome of healthy office workers.Ecotoxicology and environmental safety · 2025Article
- The gut-lung axis: a new perspective on the impact of atmospheric particulate matter exposure on chronic obstructive pulmonary disease.Frontiers in immunology · 2025Review
- Microbial hallmarks of the respiratory tract in lung cancer: a meta-analysis.Frontiers in microbiomes · 2025Article
- Air-Pollution-Mediated Microbial Dysbiosis in Health and Disease: Lung-Gut Axis and Beyond.Journal of xenobiotics · 2024Review
- Inno4Vac Workshop Report Part 2: RSV-Controlled Human Infection Model (CHIM) Strain Selection and Immune Assays for RSV CHIM Studies, November 2021, MHRA, UK.Influenza and other respiratory viruses · 2024Review
- The microbiome of Total Suspended Particles (TSP) and its influence on the respiratory microbiome of healthy office workers.bioRxiv : the preprint server for biology · 2024Article
- Article
- Genome-wide mapping of gene-microbe interactions in the murine lung microbiota based on quantitative microbial profiling.Animal microbiome · 2023Article
- Characterization of the lung microbiome and inflammatory cytokine levels in women exposed to environmental risk factors: A pilot study.Immunity, inflammation and disease · 2023Article
- The possible role of particulate matter on the respiratory microbiome: evidence from in vivo to clinical studies.Archives of toxicology · 2023Review
- Exposure to particulate matter 2.5 leading to lung microbiome disorder and the alleviation effect ofInternational journal of occupational medicine and environmental health · 2022Article
- Deleterious Effect of Air Pollution on Human Microbial Community and Bacterial Flora: A Short Review.International journal of environmental research and public health · 2022Review
- Review
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 3 countries.
Funding
Abstract
backgroundDomestic combustion of biomass fuels, such as wood, charcoal, crop residue and dung causes Household Air Pollution (HAP). These inhaled particulates affect more than half of the world's population, causing respiratory problems such as infection and inflammatory lung disease. We examined whether the presence of black carbon in alveolar macrophages was associated with alterations in the lung microbiome in a Malawi population.
methodsBronchoalveolar lavage samples from 44 healthy adults were sequenced using 16S rDNA amplification to assess microbial diversity, richness and relative taxa abundance. Individuals were classified as high or low particulate exposure as determined by questionnaire and the percentage of black carbon within their alveolar macrophages.
resultsSubjects in the low and high particulate groups did not differ in terms of source of fuels used for cooking or lighting. There was no difference in alpha or beta diversity by particulate group. Neisseria and Streptococcus were significantly more abundant in samples from high particulate exposed individuals, and Tropheryma was found less abundant. Petrobacter abundance was higher in people using biomass fuel for household cooking and lighting, compared with exclusive use of electricity.
conclusionsHealthy adults in Malawi exposed to higher levels of particulates have higher abundances of potentially pathogenic bacteria (Streptococcus, Neisseria) within their lung microbiome. Domestic biomass fuel use was associated with an uncommon environmental bacterium (Petrobacter) associated with oil-rich niches.
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