Evidence map›Paper›PMID 27514591›Full record

ReviewClinics in chest medicine2016

Pulmonary Alveolar Microlithiasis.

Atsushi Saito, Francis X McCormack

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Clinics in chest medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Pulmonary alveolar microlithiasis: a rare case report from Syria.Annals of medicine and surgery (2012) · 2023
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Pulmonary Alveolar Microlithiasis.Seminars in respiratory and critical care medicine · 2020
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Atsushi SaitoDepartment of Biochemistry, Sapporo Medical University, School of Medicine, Sapporo 0608543, Japan; Department of Respiratory Medicine and Allergology, Sapporo Medical University, School of Medicine, Sapporo 0608556, Japan.
Francis X McCormackDivision of Pulmonary, Critical Care, and Sleep Medicine, The University of Cincinnati, MSB 6165, 231 Albert Sabin Way, Cincinnati, OH 45267-0564, USA. Electronic address: frank.mccormack@uc.edu.
Sabin Vaccine Institute · USSapporo Medical University · JP

Funding

Pathogenesis-Driven Therapeutic Development for Pulmonary Alveolar MicrolithiasisR01HL127455 · NHLBI · UNIVERSITY OF CINCINNATI · PI MCCORMACK, FRANCIS XAVIER · 2015 to 2018
$1.6M
NHLBI NIH HHS R01 HL127455
6 · The paper itself

Abstract

Pulmonary alveolar microlithiasis (PAM) is a genetic lung disorder that is characterized by the accumulation of calcium phosphate deposits in the alveolar spaces of the lung. Mutations in the type II sodium phosphate cotransporter, NPT2b, have been reported in patients with PAM. PAM progresses gradually, often producing incremental dyspnea on exertion, desaturation in young adulthood, and respiratory insufficiency by late middle age. Treatment remains supportive, including supplemental oxygen therapy. For patients with end-stage disease, lung transplantation is available as a last resort. The recent development of a laboratory animal model has revealed several promising treatment approaches for future trials.

Indexed as

Lung TransplantationOxygen Inhalation TherapyBone Density Conservation AgentsCalcinosisCalcium PhosphatesEtidronic AcidGenetic Diseases, InbornHumansLung DiseasesMutationRadiography, ThoracicRespiratory InsufficiencySodium-Phosphate Cotransporter Proteins, Type IIbTomography, X-Ray ComputedBone Density Conservation Agentscalcium phosphateCalcium PhosphatesEtidronic AcidSodium-Phosphate Cotransporter Proteins, Type IIbCongenital diseasePhosphate homeostasisPulmonary alveolar microlithiasisSLC34A2Type II b sodium-phosphate cotransporter (NPT2B)

Identifiers

PMID27514591
PMCPMC4987712
OpenAlexW2472932959

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.