Evidence map›Paper›PMID 27514479›Full record

ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2016

The kielin/chordin-like protein KCP attenuates nonalcoholic fatty liver disease in mice.

Abdul Soofi, Katherine I Wolf, Egon J Ranghini, Mohammad A Amin, Gregory R Dressler

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Gastrointestinal and liver physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Identification of Growth-Related GeneAnimals : an open access journal from MDPI · 2024
    Article
  2. Kielin/chordin-like protein deficiency causes cardiac aging in male mice.Journal of molecular medicine (Berlin, Germany) · 2023
    Article
  3. Article
  4. BMP Signalling at the Crossroad of Liver Fibrosis and Regeneration.International journal of molecular sciences · 2017
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Abdul SoofiDepartment of Pathology, University of Michigan, Ann Arbor, Michigan; and.
Katherine I WolfDepartment of Pathology, University of Michigan, Ann Arbor, Michigan; and.
Egon J RanghiniDepartment of Pathology, University of Michigan, Ann Arbor, Michigan; and.
Mohammad A AminDepartment of Internal Medicine, University of Michigan, Ann Arbor, Michigan.
Gregory R DresslerDepartment of Pathology, University of Michigan, Ann Arbor, Michigan; and dressler@umich.edu.
University of Michigan–Ann Arbor · US

Funding

Research Supplement to Promote Diversity in Health Related ResearchR01DK054740 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DRESSLER, GREGORY R · 1999 to 2024
$9.0M
Epigenetic Regulation of Kidney DevelopmentR01DK073722 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DRESSLER, GREGORY R · 2006 to 2020
$4.6M
Cell Signaling in Developing EpitheliaR01DK062914 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DRESSLER, GREGORY R · 2003 to 2010
$1.8M
NIDDK NIH HHS R01 DK054740NIDDK NIH HHS R01 DK062914NIDDK NIH HHS R01 DK073722
6 · The paper itself

Abstract

Nonalcoholic fatty liver disease (NAFLD) is a common cause of chronic liver disease and is increasing with the rising rate of obesity in the developed world. Signaling pathways known to influence the rate of lipid deposition in liver, known as hepatic steatosis, include the transforming growth factor (TGF) superfamily, which function through the SMAD second messengers. The kielin/chordin-like protein (KCP) is a large secreted protein that can enhance bone morphogenetic protein signaling while suppressing TGF-β signaling in cells and in genetically modified mice. In this report, we show that aging KCP mutant (Kcp

Indexed as

AgingAnimalsCarrier ProteinsDiet, High-FatDisease Models, AnimalGene Expression ProfilingLiverMiceMice, KnockoutNon-alcoholic Fatty Liver DiseasePhosphorylationSignal TransductionSmad3 ProteinTransforming Growth Factor betaCarrier Proteinskielin-chordin-like protein, mouseSmad3 ProteinTransforming Growth Factor betahepatic steatosisKCPmouse modelTGF-β

Identifiers

PMID27514479
PMCPMC5142198
OpenAlexW2510059284

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.