Evidence map›Paper›PMID 27514293›Full record

ArticleEuropean neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology2016

Degree connectivity in body dysmorphic disorder and relationships with obsessive and compulsive symptoms.

Jan C Beucke, Jorge Sepulcre, Ulrike Buhlmann, Norbert Kathmann, Teena Moody, Jamie D Feusner

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Body Dysmorphic Disorder: 21st Century Challenges.International journal of dermatology · 2025
    Review
  3. Article
  4. Body dysmorphic disorder.Nature reviews. Disease primers · 2024
    Review
  5. Physical Activity and Exercise Addiction During the Covid-19 Pandemic in Italy.International journal of mental health and addiction · 2022
    Article
  6. Effects of visual attention modulation on dynamic functional connectivity during own-face viewing in body dysmorphic disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021
    Article
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Jan C BeuckeDepartment of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany; Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, USA. Electronic address: jan.beucke@hu-berlin.de.
Jorge SepulcreDepartment of Radiology, Massachusetts General Hospital, Boston, MA, USA; Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, USA; Department of Psychology and Center for Brain Science, Harvard University, Cambridge, MA, USA.
Ulrike BuhlmannDepartment of Psychology, Westfälische Wilhelms-Universität Münster, Münster, Germany.
Norbert KathmannDepartment of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany.
Teena MoodyDepartment of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, CA, USA.
Jamie D FeusnerDepartment of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, CA, USA.
Humboldt-Universität zu Berlin · DENeurobehavioral Systems · USAthinoula A. Martinos Center for Biomedical Imaging · USUniversity of Münster · DE

Funding

Anxiety and reward interaction and prediction of outcomes in anorexia nervosaR01MH105662 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FEUSNER, JAMIE · 2015 to 2019
$2.3M
Common and Distinct Phenotypes of Body Dysmorphic Disorder and Anorexia NervosaR01MH093535 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FEUSNER, JAMIE · 2011 to 2015
$2.0M
A Storage Area Network for Structural and Functional Image AnalysisS10RR023401 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI FISCHL, BRUCE · 2009 to 2009
$2.0M
Cognitive-Behavioral Therapy and Glutamate in Cingulate Gyrus in OCDR01MH085900 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FEUSNER, JAMIE, O'NEILL, JOSEPH · 2011 to 2014
$1.8M
SILICON GRAPHICS PRISM EXTREME 128P/1TBS10RR023043 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI SORENSEN, ALMA GREGORY · 2006 to 2006
$1.5M
Body Dysmorphic Disorder: clinical and neurobiological featuresK23MH079212 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FEUSNER, JAMIE · 2007 to 2011
$752k
NCRR NIH HHS S10 RR023043NCRR NIH HHS S10 RR023401NIMH NIH HHS K23 MH079212NIMH NIH HHS R01 MH085900NIMH NIH HHS R01 MH093535NIMH NIH HHS R01 MH105662
6 · The paper itself

Abstract

Individuals with body dysmorphic disorder (BDD) and obsessive-compulsive disorder (OCD) are categorized within the same major diagnostic group and both show regional brain hyperactivity in the orbitofrontal cortex (OFC) and the basal ganglia during symptom provocation. While recent studies revealed that degree connectivity of these areas is abnormally high in OCD and positively correlates with symptom severity, no study has investigated degree connectivity in BDD. We used functional magnetic resonance imaging (fMRI) to compare the local and distant degree of functional connectivity in all brain areas between 28 unmedicated BDD participants and 28 demographically matched healthy controls during a face-processing task. Correlational analyses tested for associations between degree connectivity and symptom severity assessed by the BDD version of the Yale-Brown obsessive-compulsive scale (BDD-Y-BOCS). Reduced local amygdalar connectivity was found in participants with BDD. No differences in distant connectivity were found. BDD-Y-BOCS scores significantly correlated with the local connectivity of the posterior-lateral OFC, and distant connectivity of the posterior-lateral and post-central OFC, respectively. These findings represent preliminary evidence that individuals with BDD exhibit brain-behavioral associations related to obsessive thoughts and compulsive behaviors that are highly similar to correlations previously found in OCD, further underscoring their related pathophysiology. This relationship could be further elucidated through investigation of resting-state functional connectivity in BDD, ideally in direct comparison with OCD and other obsessive-compulsive and related disorders.

Indexed as

AmygdalaBasal GangliaBody Dysmorphic DisordersFemaleHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleNeural PathwaysObsessive-Compulsive DisorderPrefrontal CortexPsychiatric Status Rating ScalesYoung AdultAmygdalaBody dysmorphic disorderConnectivityObsessive–compulsive disorderOrbitofrontal cortex

Identifiers

PMID27514293
PMCPMC5316290
OpenAlexW2500148698

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.