ArticlePreventive medicine2016
Risk factors for late-life depression: A prospective cohort study among older women.
Article in Preventive medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed, 2 syntheses or guidelines pooled it, 102 citations in OpenAlex.
- Association between cigarette smoking and the risk of major psychiatric disorders: a systematic review and meta-analysis in depression, schizophrenia, and bipolar disorder.Frontiers in medicine · 2025Pooled it
- Associations of cannabis use, tobacco use, and incident anxiety, mood, and psychotic disorders: a systematic review and meta-analysis.Psychological medicine · 2024Pooled it
- Effects of Vitamin DThe Journal of clinical psychiatry · 2023Trial
- Relationship among frailty, nutrition, depression and quality of life in the older population.BMC geriatrics · 2026Article
- Prevention of late-life depression: a framework and prospectus for research.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Depression and Multimorbidity among Older Indians Residing in Front-Runner, Achiever and Aspirant States: Insight from Longitudinal Ageing Study in India (LASI) - Wave I.Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine · 2026Article
- Late-Onset Depression in an Aging World: A Multidimensional Perspective on Risks, Mechanisms, and Treatment.Geriatrics (Basel, Switzerland) · 2026Review
- Predicting 3-year depressive symptoms among middle-aged and older adults in rural China using random forest: insights from the China health and retirement longitudinal study.BMC psychology · 2025Article
- The global burden of depression attributable to childhood sexual abuse, intimate partner violence, and bullying victimization from 1990 to 2021: an analysis based on the global burden of disease study.Annals of general psychiatry · 2025Article
- The association between physical activity and depressive symptoms in U.S. adults is modulated by sleep duration: gender disparities.Discover mental health · 2025Article
- Childhood maltreatment, social connectedness, and depression: A prospective analysis of trajectories over time.Developmental psychology · 2025Article
- Prediction of late-onset depression in the elderly Korean population using machine learning algorithms.Scientific reports · 2025Article
- Knee Extensor Muscle Strength Associated with the Onset of Depression in Older Japanese Women: The Otassha Study.Nutrients · 2024Article
- Somatic disease burden and depression risk in late life: a community-based study.Epidemiology and psychiatric sciences · 2024Article
- A Comparison of Cognitive Performance, Depressive Symptoms, and Incidence of Falls in Brazilian Older Women with and without a Confirmed History of COVID-19.International journal of environmental research and public health · 2023Article
- Moderators of the Association Between Contact Frequency With Non-Cohabitating Adult Children and Depressive Symptoms Among Community-Dwelling Older Adults.Psychiatry investigation · 2023Article
- Social Isolation, Loneliness, and Depressive Symptoms: A Twelve-Year Population Study of Temporal Dynamics.The journals of gerontology. Series B, Psychological sciences and social sciences · 2023Article
- The effect of depressive symptoms on disability-free survival in healthy older adults: A prospective cohort study.Acta psychiatrica Scandinavica · 2023Article
- The sociodemographic characteristics and clinical features of the late-life depression patients: results from the Beijing Anding Hospital mental health big data platform.BMC psychiatry · 2022Observational
- Lower grip strength and insufficient physical activity can increase depressive symptoms among middle-aged and older European adults: a longitudinal study.BMC geriatrics · 2022Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Depression prevention requires identifying key risk contributors. Prior studies have identified several factors related to late-life depression but have seldom addressed factors jointly or in dose-response fashion. This study aimed to examine a wide range of potential predisposing factors and to estimate individual and joint contributions to risk of late-life depression in women. A total of 21,728 women aged ≥65years, without prior depression, in the Nurses' Health Study conducted in the United States were followed from 2000 to 2010. Demographic, social, lifestyle/behavioral and health variables were selected a priori from the literature or previous findings in this cohort. Depression was defined as physician/clinician-diagnosed depression, regular antidepressant use, or the presence of severe depressive symptoms. During 10-year follow-up, 3945 incident cases were identified. After simultaneous multivariable-adjustment, multiple factors in the domains of social stress (lower self-rated societal position and high volume of caregiving to disabled/ill relatives), unfavorable lifestyle (smoking, physical inactivity, heavy or binge drinking), and poor physical health (multiple comorbidity burden, excessive sleep, difficulty falling/staying asleep, bodily pain, and physical/functional limitation or disability) were significantly associated with higher depression risk; many featured dose-response relationships. Sensitivity analyses that excluded outcomes within 2years yielded similar estimates. The total population attributable fraction for all factors was 55.5%. Physical/functional limitation accounted for one-quarter of population attributable fraction, followed by problematic sleep, inadequate exercise, and pain (combining for one-third of population attributable fraction). Efforts to remediate or prevent these factors may contribute to an efficient strategy for late-life depression prevention in women.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.