ArticlePLoS neglected tropical diseases2016
Invasive Non-typhoidal Salmonella Infections in Asia: Clinical Observations, Disease Outcome and Dominant Serovars from an Infectious Disease Hospital in Vietnam.
Article in PLoS neglected tropical diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 3 of them syntheses that pooled it.
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Who cites it
53 citing papers in PubMed, 3 syntheses or guidelines pooled it, 86 citations in OpenAlex.
- Invasive non-typhoidal Salmonella infections in China (1961-2024): a retrospective systematic analysis of multicentre case reports.Journal of global health · 2026Pooled it
- Prevalence and distribution of non-typhoidalEpidemiology and infection · 2023Pooled it
- Complications and mortality of non-typhoidal salmonella invasive disease: a global systematic review and meta-analysis.The Lancet. Infectious diseases · 2022Pooled it
- Pan genome clustering identifies a novel mosaic prophage specific to Salmonella Enteritidis lineage associated with the invasive disease in India.PLoS neglected tropical diseases · 2026Article
- Genomic census of invasive nontyphoidal Salmonella infections reveals global and local human-to-human transmission.Nature medicine · 2025Article
- Article
- Epidemiology of NontyphoidalAnnals of laboratory medicine · 2025Article
- Worldwide Population Dynamics ofGenes · 2025Article
- Article
- Foodborne Infections andVaccines · 2024Review
- Non-typhoidalJAC-antimicrobial resistance · 2024Review
- Genomic and Transcriptomic Comparison Between Invasive Non-TyphoidalMicroorganisms · 2024Article
- Review
- A review and meta-analysis of non-typhoidalOne health (Amsterdam, Netherlands) · 2024Review
- Clinical-Microbiological Study of Nontyphoidal Salmonella Infections from Karnataka, India.Scientifica · 2024Article
- Changing epidemiology and antimicrobial susceptibility of bloodstream infections at a Vietnamese infectious diseases hospital (2010-2020).npj antimicrobials and resistance · 2024Article
- Invasive and Non-Invasive Human Salmonellosis Cases Admitted between 2015 and 2021 in Four Suburban Hospitals in the Metropolitan Area of Milan (Italy): A Multi-Center Retrospective Study.Pathogens (Basel, Switzerland) · 2023Article
- The Rise of Non-typhoidal Salmonella Infections in India: Causes, Symptoms, and Prevention.Cureus · 2023Review
- Pyogenic sacroiliitis caused by Salmonella schwarzengrund in a young healthy woman: a case report and literature review.International journal of emergency medicine · 2023Article
- L-leucine increases the sensitivity of drug-resistantFrontiers in microbiology · 2023Article
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Authors and funding
11 authors at 5 institutions in 4 countries.
Funding
Abstract
Invasive non-typhoidal Salmonella (iNTS) infections are now a well-described cause of morbidity and mortality in children and HIV-infected adults in sub-Saharan Africa. In contrast, the epidemiology and clinical manifestations of iNTS disease in Asia are not well documented. We retrospectively identified >100 cases of iNTS infections in an infectious disease hospital in Southern Vietnam between 2008 and 2013. Clinical records were accessed to evaluate demographic and clinical factors associated with iNTS infection and to identify risk factors associated with death. Multi-locus sequence typing and antimicrobial susceptibility testing was performed on all organisms. Of 102 iNTS patients, 71% were HIV-infected, >90% were adults, 71% were male and 33% reported intravenous drug use. Twenty-six/92 (28%) patients with a known outcome died; HIV infection was significantly associated with death (p = 0.039). S. Enteritidis (Sequence Types (ST)11) (48%, 43/89) and S. Typhimurium (ST19, 34 and 1544) (26%, 23/89) were the most commonly identified serovars; S. Typhimurium was significantly more common in HIV-infected individuals (p = 0.003). Isolates from HIV-infected patients were more likely to exhibit reduced susceptibility against trimethoprim-sulfamethoxazole than HIV-negative patients (p = 0.037). We conclude that iNTS disease is a severe infection in Vietnam with a high mortality rate. As in sub-Saharan Africa, HIV infection was a risk factor for death, with the majority of the burden in this population found in HIV-infected adult men.
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Registered trials
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