Evidence map›Paper›PMID 27513922›Full record

ArticleJournal of orthopaedic research : official publication of the Orthopaedic Research Society2017

Differences in sensitivity to microstructure between cyclic- and impact-based microindentation of human cortical bone.

Sasidhar Uppuganti, Mathilde Granke, Mary Kate Manhard, Mark D Does, Daniel S Perrien, Donald H Lee, Jeffry S Nyman

Abstract read
In one paragraph

Article in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Differences and similarities in cortical bone of the femur between donors with and without type 2 diabetes.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. In Vitro-Induced High Sugar Environments Deteriorate Human Cortical Bone Elastic Modulus and Fracture Toughness.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020
    Article
  7. PTH and bone material strength in hypoparathyroidism as measured by impact microindentation.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2020
    Article
  8. Bone material strength in normoglycemic and hyperglycemic black and white older adults.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2019
    Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Sasidhar UppugantiDepartment of Orthopaedic Surgery & Rehabilitation, Vanderbilt University Medical Center, 1215 21st Ave. S. Suite 4200, Nashville, Tennessee, 37232.
Mathilde GrankeDepartment of Orthopaedic Surgery & Rehabilitation, Vanderbilt University Medical Center, 1215 21st Ave. S. Suite 4200, Nashville, Tennessee, 37232.
Mary Kate ManhardDepartment of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee, 37232.
Mark D DoesDepartment of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee, 37232.
Daniel S PerrienDepartment of Orthopaedic Surgery & Rehabilitation, Vanderbilt University Medical Center, 1215 21st Ave. S. Suite 4200, Nashville, Tennessee, 37232.
Donald H LeeDepartment of Orthopaedic Surgery & Rehabilitation, Vanderbilt University Medical Center, 1215 21st Ave. S. Suite 4200, Nashville, Tennessee, 37232.
Jeffry S NymanDepartment of Orthopaedic Surgery & Rehabilitation, Vanderbilt University Medical Center, 1215 21st Ave. S. Suite 4200, Nashville, Tennessee, 37232.
Vanderbilt University Medical Center · USVanderbilt University · US

Funding

The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
The Roles of Collagen and Water in the Fracture Resistance of BoneR01AR063157 · NIAMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI NYMAN, JEFFRY STEPHEN · 2012 to 2025
$3.9M
Bone Fracture Risk Assessment Through Bound - and Pore - Water MRIR01EB014308 · NIBIB · VANDERBILT UNIVERSITY · PI DOES, MARK D · 2012 to 2020
$3.2M
MRI Toolbox for Rodent Brain Microstructure ImagingR01EB019980 · NIBIB · VANDERBILT UNIVERSITY · PI DOES, MARK D · 2016 to 2019
$1.8M
Novel ultrahigh resolution microCT imaging systemS10RR027631 · NCRR · VANDERBILT UNIVERSITY · PI PERRIEN, DANIEL S · 2010 to 2010
$460k
Aging and Diabetes-Related Factors Compromising Bone Fracture ResistanceI01BX001018 · VA · VETERANS HEALTH ADMINISTRATION · PI NYMAN, JEFFRY STEPHEN · 2011 to 2014
–
Interventions and Mechanisms of Disuse OsteopeniaIK2BX001634 · VA · VETERANS HEALTH ADMINISTRATION · PI PERRIEN, DANIEL S · 2013 to 2015
–
BLRD VA I01 BX001018BLRD VA IK2 BX001634NCATS NIH HHS UL1 TR000445NCRR NIH HHS S10 RR027631NIAMS NIH HHS R01 AR063157NIBIB NIH HHS R01 EB014308NIBIB NIH HHS R01 EB019980
6 · The paper itself

Abstract

Unlike the known relationships between traditional mechanical properties and microstructural features of bone, the factors that influence the mechanical resistance of bone to cyclic reference point microindention (cRPI) and impact microindention (IMI) have yet to be identified. To determine whether cRPI and IMI properties depend on microstructure, we indented the tibia mid-shaft, the distal radius, and the proximal humerus from 10 elderly donors using the BioDent and OsteoProbe (neighboring sites). As the only output measure of IMI, bone material strength index (BMSi) was significantly different across all three anatomical sites being highest for the tibia mid-shaft and lowest for the proximal humerus. Total indentation distance (inverse of BMSi) was higher for the proximal humerus than for the tibia mid-shaft but was not different between other anatomical comparisons. As a possible explanation for the differences in BMSi, pore water, as determined by

Indexed as

Mechanical PhenomenaAgedAged, 80 and overCortical BoneFemaleHumansMalebone strengthbound waterpore waterporosityreference point indentation

Identifiers

PMID27513922
PMCPMC5530367
OpenAlexW2517425946

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.