ArticlePloS one2016
D-Dimer Levels Predict Myocardial Injury in ST-Segment Elevation Myocardial Infarction: A Cardiac Magnetic Resonance Imaging Study.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 47 citations in OpenAlex.
- Dietary Supplementation with Selenium and Coenzyme QNutrients · 2021Trial
- Admission BNP-dominant biomarker phenotypes and in-hospital heart failure or cardiogenic shock in STEMI: a retrospective research note.BMC research notes · 2026Article
- Combined complement and coagulation activation in ST-elevation myocardial infarction: associations with myocardial injury and dysfunction.Frontiers in immunology · 2025Article
- Short-term recurrent coronary artery thrombosis with acute myocardial infarction in a patient with aplastic anemia-paroxysmal nocturnal hemoglobinuria syndrome: a case report.Frontiers in cardiovascular medicine · 2025Article
- The Prognostic Value of D-Dimer in Patients with Acute Myocardial Infarction: A Retrospective Longitudinal Cohort Study in Taiwan.Acta Cardiologica Sinica · 2024Article
- Sex differences in the association between D-dimer and the incidence of acute kidney injury in patients admitted with ST-segment elevation myocardial infarction: a retrospective observational study.Internal and emergency medicine · 2024Observational
- De Winter electrocardiogram pattern due to type A aortic dissection: a case report.BMC cardiovascular disorders · 2022Article
- Validation of plasma D-dimer in Chinese patients with acute non-ST segment elevation myocardial infarction.Frontiers in cardiovascular medicine · 2022Article
- The Predictive Value of Barthel Score, Sequential Organ Failure Assessment Score, and D-Dimer in the 28-Day Prognosis of Patients with Non-ST Elevation Myocardial Infarction: A Retrospective Study of 358 Patients.International journal of general medicine · 2022Article
- Coronavirus 2019 Infectious Disease Epidemic: Where We Are, What Can Be Done and Hope For.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2021Article
- The looming storm: Blood and cytokines in COVID-19.Blood reviews · 2021Review
- Predictive value of elevated alanine aminotransferase for in-hospital mortality in patients with acute myocardial infarction.BMC cardiovascular disorders · 2021Article
- Gender-Related Difference in D-Dimer Level Predicts In-Hospital Heart Failure after Primary PCI for ST-Segment Elevation Myocardial Infarction.Disease markers · 2021Article
- Immune biomarkers link air pollution exposure to blood pressure in adolescents.Environmental health : a global access science source · 2020Article
- ST-Segment Elevation in Patients with Covid-19 - A Case Series.The New England journal of medicine · 2020Article
- Gender-Specific Predictive Markers of Poor Prognosis for Patients with Acute Myocardial Infarction During a 6-Month Follow-up.Journal of cardiovascular translational research · 2020Article
- Hospital mortality in acute coronary syndrome: adjustment of GRACE score by D-dimer enables a more accurate prediction in a prospective cohort study.BMC cardiovascular disorders · 2019Observational
- Markers of Thrombin Generation Are Associated With Long-Term Clinical Outcome in Patients With ST-Segment Elevation Myocardial Infarction.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis · 2018Article
- Enhanced Stability of Gold Magnetic Nanoparticles with Poly(4-styrenesulfonic acid-co-maleic acid): Tailored Optical Properties for Protein Detection.Nanoscale research letters · 2017Article
- Observational
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Authors and funding
14 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesElevated D-dimer levels on admission predict prognosis in patients undergoing primary percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI), but the association of D-dimer levels with structural markers of myocardial injury in these patients is unknown.
methodsWe performed cardiac magnetic resonance (CMR) imaging in 208 patients treated with primary PCI for STEMI. CMR was performed a median of 3 days after the index procedure. Of the 208 patients studied, 75 patients had D-dimer levels above the normal range on admission (>0.5 μg/mL; high D-dimer group) while 133 had normal levels (≤0.5 μg/mL; low D-dimer group). The primary outcome was myocardial infarct size assessed by CMR. Secondary outcomes included area at risk (AAR), microvascular obstruction (MVO) area, and myocardial salvage index (MSI).
resultsIn CMR analysis, myocardial infarct size was larger in the high D-dimer group than in the low D-dimer group (22.3% [16.2-30.5] versus 18.8% [10.7-26.7]; p = 0.02). Compared to the low D-dimer group, the high D-dimer group also had a larger AAR (38.1% [31.7-46.9] versus 35.8% [24.2-45.3]; p = 0.04) and a smaller MSI (37.7 [28.2-46.9] versus 47.1 [33.2-57.0]; p = 0.01). In multivariate analysis, high D-dimer levels were significantly associated with larger myocardial infarct (OR 2.59; 95% CI 1.37-4.87; p<0.01) and lower MSI (OR 2.62; 95% CI 1.44-4.78; p<0.01).
conclusionsIn STEMI patients undergoing primary PCI, high D-dimer levels on admission were associated with a larger myocardial infarct size, a greater extent of AAR, and lower MSI, as assessed by CMR data. Elevated initial D-dimer level may be a marker of advanced myocardial injury in patients treated with primary PCI for STEMI.
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