ArticlePloS one2016
Microstructural Correlates of Emotional Attribution Impairment in Non-Demented Patients with Amyotrophic Lateral Sclerosis.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Neural processing of social interaction: Coordinate-based meta-analytic evidence from human neuroimaging studies.Human brain mapping · 2019Pooled it
- Decision making in frontotemporal dementia: neuropsychological and neuroimaging assessments.Frontiers in neuroscience · 2025Review
- How to detect affect recognition alterations in amyotrophic lateral sclerosis.Journal of neurology · 2024Article
- Limbic Network and Papez Circuit Involvement in ALS: Imaging and Clinical Profiles in GGGGCC Hexanucleotide Carriers inBiology · 2024Article
- Uncinate fasciculus microstructural organisation and emotion recognition in schizophrenia: controlling for hit rate bias.Frontiers in behavioral neuroscience · 2024Article
- The Spectrum of Cognitive Dysfunction in Amyotrophic Lateral Sclerosis: An Update.International journal of molecular sciences · 2023Review
- Clinical usability of the Story-Based Empathy Task (SET) in non-demented ALS patients.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Article
- Investigating the contribution of white matter hyperintensities and cortical thickness to empathy in neurodegenerative and cerebrovascular diseases.GeroScience · 2022Article
- Social cognition in the FTLD spectrum: evidence from MRI.Journal of neurology · 2022Review
- Pallidal functional connectivity changes are associated with disgust recognition in pure motor amyotrophic lateral sclerosis.NeuroImage. Clinical · 2022Article
- Validity and diagnostics of the Reading the Mind in the Eyes Test (RMET) in non-demented amyotrophic lateral sclerosis (ALS) patients.Frontiers in psychology · 2022Article
- Emotional Processing and Experience in Amyotrophic Lateral Sclerosis: A Systematic and Critical Review.Brain sciences · 2021Review
- Unraveling Moral Reasoning in Amyotrophic Lateral Sclerosis: How Emotional Detachment Modifies Moral Judgment.Frontiers in psychology · 2020Article
- Empathy In Neurodegenerative Diseases: A Systematic Review.Neuropsychiatric disease and treatment · 2019Review
- White matter pathways and social cognition.Neuroscience and biobehavioral reviews · 2018Review
- Social Cognition through the Lens of Cognitive and Clinical Neuroscience.BioMed research international · 2018Review
- Abnormal Functional Connectivity Density in Amyotrophic Lateral Sclerosis.Frontiers in aging neuroscience · 2018Article
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Impairments in the ability to recognize and attribute emotional states to others have been described in amyotrophic lateral sclerosis patients and linked to the dysfunction of key nodes of the emotional empathy network. Microstructural correlates of such disorders are still unexplored. We investigated the white-matter substrates of emotional attribution deficits in a sample of amyotrophic lateral sclerosis patients without cognitive decline. Thirteen individuals with either probable or definite amyotrophic lateral sclerosis and 14 healthy controls were enrolled in a Diffusion Tensor Imaging study and administered the Story-based Empathy Task, assessing the ability to attribute mental states to others (i.e., Intention and Emotion attribution conditions). As already reported, a significant global reduction of empathic skills, mainly driven by a failure in Emotion Attribution condition, was found in amyotrophic lateral sclerosis patients compared to healthy subjects. The severity of this deficit was significantly correlated with fractional anisotropy along the forceps minor, genu of corpus callosum, right uncinate and inferior fronto-occipital fasciculi. The involvement of frontal commissural fiber tracts and right ventral associative fronto-limbic pathways is the microstructural hallmark of the impairment of high-order processing of socio-emotional stimuli in amyotrophic lateral sclerosis. These results support the notion of the neurofunctional and neuroanatomical continuum between amyotrophic lateral sclerosis and frontotemporal dementia.
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