ArticlePloS one2016
Ethanol and Acetaminophen Synergistically Induce Hepatic Aggregation and TCH346-Insensitive Nuclear Translocation of GAPDH.
Natasha T Snider, Daniel A Portney, Helen H Willcockson, Dhiman Maitra, Hope C Martin, Joel K Greenson, M Bishr Omary
Open access · goldAbstract read
In one paragraphArticle in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
0.4field-weighted citation impact, top 26% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 2 citations in OpenAlex.
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
7 authors at 2 institutions in 1 country.
Natasha T SniderDepartment of Cell Biology and Physiology, University of North Carolina, Chapel Hill, NC, 27599, United States of America.
Daniel A PortneyDepartment of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, 48109, United States of America.
Helen H WillcocksonDepartment of Cell Biology and Physiology, University of North Carolina, Chapel Hill, NC, 27599, United States of America.
Dhiman MaitraDepartment of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, 48109, United States of America.
Hope C MartinDepartment of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, 48109, United States of America.
Joel K GreensonDepartment of Pathology, University of Michigan, Ann Arbor, MI, 48109, United States of America.
M Bishr OmaryDepartment of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, 48109, United States of America.
University of Michigan–Ann Arbor · USUniversity of North Carolina at Chapel Hill · US
Funding
PILOT AND FEASIBILITY STUDIESP30DK034987 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ROBERT S. SANDLER · 1985 to 2026
$30.5MUniversity of Michigan Center for Gastrointestinal ResearchP30DK034933 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI OWYANG, CHUNG · 1986 to 2021
$22.5MRegulation and Dynamics of Keratins in Digestive OrgansR01DK052951 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI OMARY, BISHR · 1997 to 2015
$4.5MInterfacing computation and engineering with digestive and metabolic physiologyR25DK088752 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MACDOUGALD, ORMOND A · 2010 to 2020
$1.1MKeratin sumoylation and its function during hepatocyte stress and liver diseaseK01DK093776 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SNIDER, NATASHA T · 2011 to 2015
$586kRole of cellular metabolism in keratin variant-mediated liver disease progressionR03DK102450 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SNIDER, NATASHA T · 2014 to 2015
$154kNIDDK NIH HHS K01 DK093776NIDDK NIH HHS P30 DK034933NIDDK NIH HHS P30 DK034987NIDDK NIH HHS R01 DK052951NIDDK NIH HHS R03 DK102450NIDDK NIH HHS R25 DK088752
6 · The paper itselfAbstract
The glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH) signals during cellular stress via several post-translational modifications that change its folding properties, protein-protein interactions and sub-cellular localization. We examined GAPDH properties in acute mouse liver injury due to ethanol and/or acetaminophen (APAP) treatment. Synergistic robust and time-dependent nuclear accumulation and aggregation of GAPDH were observed only in combined, but not individual, ethanol/APAP treatments. The small molecule GAPDH-targeting compound TCH346 partially attenuated liver damage possibly via mitochondrial mechanisms, and independent of nuclear accumulation and aggregation of GAPDH. These findings provide a novel potential mechanism for hepatotoxicity caused by combined alcohol and acetaminophen exposure.
Indexed as
AcetaminophenAnalgesics, Non-NarcoticAnimalsCell NucleusCentral Nervous System DepressantsChemical and Drug Induced Liver InjuryDrug SynergismEthanolFemaleGlyceraldehyde-3-Phosphate DehydrogenasesLiverMiceMice, Inbred C57BLOxepinsProtein TransportAcetaminophenAnalgesics, Non-NarcoticCentral Nervous System Depressantsdibenzo(b,f)oxepin-10-ylmethyl-methyl-prop-2-ynyl-amineEthanolGlyceraldehyde-3-Phosphate DehydrogenasesOxepins
Identifiers
PMID27513663
PMCPMC4981434
OpenAlexW2515818459
What OpenQuestion holds
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LicenceCC BY
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