Evidence map›Paper›PMID 27513554›Full record

ReviewFertility and sterility2016

Environmental influences on reproductive health: the importance of chemical exposures.

Aolin Wang, Amy Padula, Marina Sirota, Tracey J Woodruff

Abstract readReview
In one paragraph

Review in Fertility and sterility, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Molecular mechanisms of folliculogenesis and oogenesis.Systems biology in reproductive medicine · 2026
    Review
  3. Review
  4. Associations of endocrine disrupting chemicals with anogenital distance across infancy.The Journal of clinical endocrinology and metabolism · 2026
    Observational
  5. Article
  6. Article
  7. Environmental and external stressors of postejaculatory sperm function.The Journal of reproduction and development · 2026
    Review
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. A high-throughput method for quantifyingbioRxiv : the preprint server for biology · 2024
    Article
  17. Article
  18. Article
  19. Fossil fuel is the common denominator between climate change and petrochemical exposures, and effects on women and children's health.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2023
    Article
  20. Article

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Aolin WangProgram on Reproductive Health and the Environment, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, San Francisco, California; Institute for Computational Health Sciences, University of California, San Francisco, San Francisco, California.
Amy PadulaProgram on Reproductive Health and the Environment, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, San Francisco, California.
Marina SirotaInstitute for Computational Health Sciences, University of California, San Francisco, San Francisco, California.
Tracey J WoodruffProgram on Reproductive Health and the Environment, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, San Francisco, California. Electronic address: Tracey.Woodruff@ucsf.edu.

Funding

Spectrum Stanford Center for clinical and Translational Research and EducationUL1TR001085 · NCATS · STANFORD UNIVERSITY · PI CULLEN, MARK RICHARD, GREENBERG, HARRY BERNARD · 2013 to 2017
$37.1M
Transdisciplinary Approach to Rapidly Identify Reproductive Toxics in Pregnant Women and NewbornsR01ES027051 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Dimitri Abrahamsson, Tracey J. Woodruff · 2016 to 2026
$6.6M
The UCSF Pregnancy Exposures to Environmental Chemicals (PEEC) Children's CenterP01ES022841 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WOODRUFF, TRACEY J. · 2013 to 2018
$3.9M
Traffic-related Air Pollution, Social Factors and Adverse Birth OutcomesR00ES021470 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PADULA, AMY MICHELLE · 2016 to 2018
$746k
Elucidating the Role of the Genetic and Environmental Determinants of Preterm Birth Using Integrative Computational ApproachesK01LM012381 · NLM · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SIROTA, MARINA · 2016 to 2018
$531k
NCATS NIH HHS UL1 TR001085NIEHS NIH HHS L40 ES023163NIEHS NIH HHS P01 ES022841NIEHS NIH HHS R00 ES021470NIEHS NIH HHS R01 ES027051NLM NIH HHS K01 LM012381
6 · The paper itself

Abstract

Chemical exposures during pregnancy can have a profound and life-long impact on human health. Because of the omnipresence of chemicals in our daily life, there is continuous contact with chemicals in food, water, air, and consumer products. Consequently, human biomonitoring studies show that pregnant women around the globe are exposed to a variety of chemicals. In this review we provide a summary of current data on maternal and fetal exposure, as well as health consequences from these exposures. We review several chemical classes, including polychlorinated biphenyls, perfluoroalkyl substances, polybrominated diphenyl ethers, phenols, phthalates, pesticides, and metals. Additionally, we discuss environmental disparities and vulnerable populations, and future research directions. We conclude by providing some recommendations for prevention of chemical exposure and its adverse reproductive health consequences.

Indexed as

Reproductive HealthBody BurdenEndocrine DisruptorsEnvironmental MonitoringEnvironmental PollutantsFemaleFetusHumansMaleMaternal ExposureMaternal-Fetal ExchangePaternal ExposurePregnancyPrenatal EducationReproductionRisk AssessmentEndocrine DisruptorsEnvironmental PollutantsChemicalenvironmental chemicalenvironmental exposurepregnancyreproductive health

Identifiers

PMID27513554
PMCPMC5158104

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.