ArticlePloS one2016
Is One Trial Sufficient to Obtain Excellent Pressure Pain Threshold Reliability in the Low Back of Asymptomatic Individuals? A Test-Retest Study.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 2 syntheses or guidelines pooled it, 94 citations in OpenAlex.
- Does aerobic exercise effect pain sensitisation in individuals with musculoskeletal pain? A systematic review.BMC musculoskeletal disorders · 2022Pooled it
- The regional effect of spinal manipulation on the pressure pain threshold in asymptomatic subjects: a systematic literature review.Chiropractic & manual therapies · 2018Pooled it
- Trial
- Dry cupping therapy combined with conventional therapy does not provide additional benefits over conventional therapy alone in patients with non-specific chronic low back pain: a randomized trial.Chiropractic & manual therapies · 2025Trial
- Ten Minutes of Core Stabilisation Exercise Result in Local Exercise-Induced Hypoalgesia in Patients With Chronic Unspecific Low Back Pain.European journal of pain (London, England) · 2025Trial
- The Effect of Praying on Endogenous Pain Modulation and Pain Intensity in Healthy Religious Individuals in Lebanon: A Randomized Controlled Trial.Journal of religion and health · 2023Trial
- Investigating interindividual variability in corticomotor reorganization during sustained hamstring pain: A randomized experimental study.Brain and behavior · 2023Trial
- Trial
- Central Sensitization and Nociplastic Pain: Shared Mechanisms in Fibromyalgia, Osteoarthritis, and Inflammatory Arthritis.Journal of pain research · 2026Review
- Temporal changes in cortical sensory processing during the transition from acute to chronic low back pain.Pain reports · 2025Article
- Intra-Rater Reliability of Pressure Pain Threshold with Different Algometers in Healthy Participants.Muscles (Basel, Switzerland) · 2025Article
- Effects of Apnea-Induced Hypoxia on Hypoalgesia in Healthy Subjects.Sports (Basel, Switzerland) · 2024Article
- Reliability of Obstacle-Crossing Parameters during Overground Walking in Young Adults.Sensors (Basel, Switzerland) · 2024Article
- Intra- and inter-session reliability of electrical detection and pain thresholds of cutaneous and muscle primary afferents in the lower back of healthy individuals.Pflugers Archiv : European journal of physiology · 2023Article
- Individual endogenous pain modulation profiles within a multidimensional context of people with cervicogenic headache - A retrospective exploratory study.Musculoskeletal science & practice · 2023Article
- Long-term consistency of clinical sensory testing measures for pain assessment.The Korean journal of pain · 2023Article
- Sensorimotor, cognitive and affective behavior according to perceived level of disability in patients with chronic low back pain: an observational cross-sectional study.Journal of musculoskeletal & neuronal interactions · 2023Observational
- Article
- Pain phenotyping and investigation of outcomes in physical therapy: An exploratory study in patients with low back pain.PloS one · 2023Article
- Inter-individual variability in mechanical pain sensation in patients with cervicogenic headache: an explorative study.Scientific reports · 2022Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The assessment of pressure pain threshold (PPT) provides a quantitative value related to the mechanical sensitivity to pain of deep structures. Although excellent reliability of PPT has been reported in numerous anatomical locations, its absolute and relative reliability in the lower back region remains to be determined. Because of the high prevalence of low back pain in the general population and because low back pain is one of the leading causes of disability in industrialized countries, assessing pressure pain thresholds over the low back is particularly of interest. The purpose of this study study was (1) to evaluate the intra- and inter- absolute and relative reliability of PPT within 14 locations covering the low back region of asymptomatic individuals and (2) to determine the number of trial required to ensure reliable PPT measurements. Fifteen asymptomatic subjects were included in this study. PPTs were assessed among 14 anatomical locations in the low back region over two sessions separated by one hour interval. For the two sessions, three PPT assessments were performed on each location. Reliability was assessed computing intraclass correlation coefficients (ICC), standard error of measurement (SEM) and minimum detectable change (MDC) for all possible combinations between trials and sessions. Bland-Altman plots were also generated to assess potential bias in the dataset. Relative reliability for both intra- and inter- session was almost perfect with ICC ranged from 0.85 to 0.99. With respect to the intra-session, no statistical difference was reported for ICCs and SEM regardless of the conducted comparisons between trials. Conversely, for inter-session, ICCs and SEM values were significantly larger when two consecutive PPT measurements were used for data analysis. No significant difference was observed for the comparison between two consecutive measurements and three measurements. Excellent relative and absolute reliabilities were reported for both intra- and inter-session. Reliable measurements can be equally achieved when using the mean of two or three consecutive PPT measurements, as usually proposed in the literature, or with only the first one. Although reliability was almost perfect regardless of the conducted comparison between PPT assessments, our results suggest using two consecutive measurements to obtain higher short term absolute reliability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.