Evidence map›Paper›PMID 27513456›Full record

ReviewFuture oncology (London, England)2017

The next generation of novel therapies for the management of relapsed multiple myeloma.

Wilson I Gonsalves, Paolo Milani, Daniel Derudas, Francis K Buadi

Registry-linked trialOpen access · greenAbstract readReview
In one paragraph

Review in Future oncology (London, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05439538 (Serum Neutrophil Gelatinase-associated Lipocalin), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05439538 unknown statusnot on this mapstarted 2022, after this paper: background citation

Serum Neutrophil Gelatinase-associated Lipocalin (NGAL) as a Predictor of Renal Injury in Patients With Multiple Myeloma

TypeobservationalSponsorAssiut UniversityRan2022 to 2025Enrolled60ConditionsMultiple Myeloma(MM)ArmsSERUM NGAL
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Enhancing proteasome-inhibitory activity and specificity of bortezomib by CD38 targeted nanoparticles in multiple myeloma.Journal of controlled release : official journal of the Controlled Release Society · 2018
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Wilson I GonsalvesThe Divisions of Hematology & Blood & Marrow Transplantation, Mayo Clinic, Rochester, MN, USA.
Paolo MilaniAmyloidosis Research & Treatment Center, Department of Molecular Medicine, Fondazione Istituto Di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo & University of Pavia, Pavia, Italy.
Daniel DerudasDepartment of Hematology, Businco Hospital, Cagliari, Italy.
Francis K BuadiThe Divisions of Hematology & Blood & Marrow Transplantation, Mayo Clinic, Rochester, MN, USA.
Mayo Clinic in Arizona · USUniversity of Cagliari · ITUniversity of Pavia · IT

Funding

Mayo Clinic Center for Translational Science ActivitiesUL1TR000135 · NCATS · MAYO CLINIC ROCHESTER · PI KHOSLA, SUNDEEP · 2012 to 2015
$41.2M
NCATS NIH HHS UL1 TR000135
6 · The paper itself

Abstract

The advent of various novel therapies such as immunomodulators and proteasome inhibitors has transformed the treatment paradigm for patients with multiple myeloma (MM). As a result, the overall survival has improved dramatically over the last decade. Despite these advances, MM remains mostly incurable and most patients experience disease relapse after enjoying a period of disease control or remission. Fortunately, the scientific community continues to make strides in developing 'next-generation' therapies for the management of patients with relapsed MM. This review will summarize the efficacy of some of the newest therapeutic agents available for the treatment of patients with relapsed MM after their upfront treatment with the original novel agents such as thalidomide, lenalidomide and bortezomib.

Indexed as

Antineoplastic AgentsClinical Trials as TopicDisease ManagementDisease ProgressionHumansMolecular Targeted TherapyMultiple MyelomaNeoplasm GradingNeoplasm Recurrence, LocalNeoplasm StagingTreatment OutcomeAntineoplastic Agentsmultiple myelomanovel agentsrelapse

Identifiers

PMID27513456
PMCPMC5134360
OpenAlexW2514534434

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.