Evidence map›Paper›PMID 27513368›Full record

ArticleAnnals of the American Thoracic Society2016

Lung Function Trajectory in Bronchiolitis Obliterans Syndrome after Allogeneic Hematopoietic Cell Transplant.

Guang-Shing Cheng, Barry Storer, Jason W Chien, Madan Jagasia, Jesse J Hubbard, Linda Burns, Vincent T Ho, Joseph Pidala, Jeanne Palmer, Laura Johnston and 5 more

Open access · greenAbstract readMulticenter Study
In one paragraph

Article in Annals of the American Thoracic Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 3 pooled it
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 3 syntheses or guidelines pooled it, 95 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 11 institutions in 1 country.

Guang-Shing Cheng1 Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.ORCID 0000-0003-4324-9634
Barry Storer1 Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Jason W Chien2 Pulmonary and Critical Care Medicine, University of Washington School of Medicine, Seattle, Washington.
Madan Jagasia4 Division of Hematology/Oncology, Vanderbilt University, Nashville, Tennessee.
Jesse J Hubbard1 Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Linda Burns5 National Marrow Donor Program, Minneapolis, Minnesota.
Vincent T Ho6 Division of Hematological Malignancies, Dana-Farber Cancer Institute, Boston, Massachusetts.
Joseph Pidala7 Department of Blood and Marrow Transplantation, H. Lee Moffitt Cancer Center, Tampa, Florida.
Jeanne Palmer8 Division of Hematology/Oncology, Mayo Clinic-Scottsdale, Scottsdale, Arizona.
Laura Johnston9 Division of Blood and Marrow Transplantation, Stanford University, Stanford, California.
Sebastian Mayer10 Department of Medicine, Weill Cornell Medical College, New York, New York.
Kristina Crothers2 Pulmonary and Critical Care Medicine, University of Washington School of Medicine, Seattle, Washington.
Iskra Pusic11 Division of Medicine and Oncology, Washington University, St. Louis, Missouri; and.
Stephanie J Lee1 Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Kirsten M Williams12 Children's Research Institute, Children's National Health System, Washington, District of Columbia.
Fred Hutch Cancer Center · USUniversity of Washington · USChildren's National · USCornell University · USDana-Farber Cancer Institute · USMayo Clinic in Arizona · USMoffitt Cancer Center · USNational Marrow Donor Program · USStanford Blood Center · USVanderbilt University · USWashington University in St. Louis · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Institutional Career Development CoreKL2TR001862 · NCATS · YALE UNIVERSITY · PI CANTLEY, LLOYD G, EDELMAN, E. JENNIFER · 2016 to 2025
$12.2M
Training and Career Development CoreU54CA163438 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI LEE, STEPHANIE J · 2011 to 2014
$3.7M
NCATS NIH HHS KL2 TR001862NCATS NIH HHS UL1 TR001863NCI NIH HHS U54 CA163438
6 · The paper itself

Abstract

rationaleThe natural history of lung function in patients with bronchiolitis obliterans syndrome (BOS) after allogeneic hematopoietic cell transplant is poorly characterized. Understanding the trajectory of lung function is necessary for prompt clinical recognition and treatment and also for the rational design of prospective studies.

objectivesTo describe the longitudinal trajectory of lung function parameters, including FEV

methodsSubjects with BOS defined by National Institutes of Health consensus guidelines criteria from a recent multicenter prospective trial of combination treatment with fluticasone, azithromycin and montelukast and a retrospective cohort from Fred Hutchinson Cancer Research Center were included. Longitudinal change in FEV MEASUREMENTS AND MAIN

resultsThe FEV

conclusionsThe FEV

Indexed as

AcetatesAdolescentAdultAgedAnti-Inflammatory AgentsAzithromycinBronchiolitis ObliteransCyclopropanesDrug Therapy, CombinationFemaleFluticasoneForced Expiratory VolumeHematopoietic Stem Cell TransplantationHumansKaplan-Meier EstimateLinear ModelsAcetatesAnti-Inflammatory AgentsAzithromycinCyclopropanesFluticasonemontelukastQuinolinesSulfidesbronchiolitis obliterans syndromeFEV1 trajectoryhematopoietic cell transplantationoutcomespulmonary complications

Identifiers

PMID27513368
PMCPMC5122479
OpenAlexW2508959463

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.