ArticleCritical care medicine2016
Acute Kidney Injury in Pediatric Severe Sepsis: An Independent Risk Factor for Death and New Disability.
Article in Critical care medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers, 4 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
92 citing papers in PubMed, 4 syntheses or guidelines pooled it, 194 citations in OpenAlex.
- Incidence of acute kidney injury-associated mortality in hospitalized children: a systematic review and meta-analysis.BMC nephrology · 2025Pooled it
- Risk factors for acute kidney injury after pediatric cardiac surgery: a meta-analysis.Pediatric nephrology (Berlin, Germany) · 2022Pooled it
- Contemporary Trends in Global Mortality of Sepsis Among Young Infants Less Than 90 Days: A Systematic Review and Meta-Analysis.Frontiers in pediatrics · 2022Pooled it
- In-Hospital Outcomes of Acute Kidney Injury After Pediatric Cardiac Surgery: A Meta-Analysis.Frontiers in pediatrics · 2021Pooled it
- Time Course of Kidney Injury Biomarkers in Children With Septic Shock: Nested Cohort Study Within the Pragmatic Pediatric Trial of Balanced Versus Normal Saline Fluid in Sepsis Trial.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2025Trial
- Acute kidney injury after in-hospital cardiac arrest.Resuscitation · 2021Trial
- Acute kidney injury after out of hospital pediatric cardiac arrest.Resuscitation · 2018Trial
- Improving pediatric post-acute kidney injury care: considerations for the clinician.Renal failure · 2026Review
- Early, frequent, yet reversible: acute kidney injury after hematopoietic stem cell transplantation in pediatric Fanconi anemia and long-term renal outcomes.Pediatric nephrology (Berlin, Germany) · 2026Article
- Blood transfusion in pediatric sepsis-associated acute kidney injury: a nationwide study of risk factors and outcomes.Pediatric nephrology (Berlin, Germany) · 2026Article
- Pediatric sepsis-associated acute kidney injury: leveraging pathophysiology for risk stratification and identification of treatable traits.Pediatric nephrology (Berlin, Germany) · 2026Review
- Acute Kidney Injury in Critically Ill Children: A Retrospective Single-Center Study.Children (Basel, Switzerland) · 2026Article
- External Validation, Molecular Signatures, and Therapeutic Relevance of Pediatric Sepsis-Associated Acute Kidney Injury Subphenotypes.Critical care medicine · 2026Observational
- Article
- Clinical profile, intensive care needs, outcome, and predictors of mortality in children with severe sepsis: Secondary analysis of FerriPedS study.The Indian journal of medical research · 2026Article
- Cystatin C for predicting acute kidney injury in critically ill children with bacterial infections: a retrospective cohort study.BMJ paediatrics open · 2026Article
- Risk factors and a nomogram for predicting severe acute kidney injury in pediatric sepsis: a retrospective study.Frontiers in pediatrics · 2026Article
- Metabolomics of Sepsis and Acute Kidney Injury in Infants and Children: Current Challenges in Prevention, Diagnosis, and Management.Infectious diseases and therapy · 2025Review
- Application of New Pediatric Sepsis Definition to a Multicenter Observational Cohort of Previously Enrolled Severe Sepsis Patients Defined by SIRS Plus Organ Dysfunction.Journal of intensive care medicine · 2025Observational
- Effect of serum creatinine changes on surgical timing and prognosis in progressive necrotizing Enterocolitis.BMC pediatrics · 2025Article
32 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
16 authors at 4 institutions in 2 countries.
Funding
Abstract
objectivesThe prevalence of septic acute kidney injury and impact on functional status of PICU survivors are unknown. We used data from an international prospective severe sepsis study to elucidate functional outcomes of children suffering septic acute kidney injury.
designSecondary analysis of patients in the Sepsis PRevalence, OUtcomes, and Therapies point prevalence study: acute kidney injury was defined on the study day using Kidney Disease Improving Global Outcomes definitions. Patients with no acute kidney injury or stage 1 acute kidney injury ("no/mild acute kidney injury") were compared with those with stage 2 or 3 acute kidney injury ("severe acute kidney injury"). The primary outcome was a composite of death or new moderate disability at discharge defined as a Pediatric Overall Performance Category score of 3 or higher and increased by 1 from baseline.
settingOne hundred twenty-eight PICUs in 26 countries. PATIENTS: Children with severe sepsis in the Sepsis PRevalence, OUtcomes, and Therapies study.
interventionsNone. MEASUREMENTS AND MAIN
resultsOne hundred two (21%) of 493 patients had severe acute kidney injury. More than twice as many patients with severe acute kidney injury died or developed new moderate disability compared with those with no/mild acute kidney injury (64% vs 30%; p < 0.001). Severe acute kidney injury was independently associated with death or new moderate disability (adjusted odds ratio, 2.5; 95% CI, 1.5-4.2; p = 0.001) after adjustment for age, region, baseline disability, malignancy, invasive mechanical ventilation, albumin administration, and the pediatric logistic organ dysfunction score.
conclusionsIn a multinational cohort of critically ill children with severe sepsis and high mortality rates, septic acute kidney injury is independently associated with further increased death or new disability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.