Evidence map›Paper›PMID 27512954›Full record

ReviewCell death & disease2016

Regulatory non-coding RNA: new instruments in the orchestration of cell death.

Ye Su, Haijiang Wu, Alexander Pavlosky, Ling-Lin Zou, Xinna Deng, Zhu-Xu Zhang, Anthony M Jevnikar

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cell death & disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 1 pooled it
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 1 synthesis or guideline pooled it, 110 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. ncRNA Editing: Functional Characterization and Computational Resources.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  9. Article
  10. Non-coding RNA research · 2024
    Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. Review
  16. Long non-coding RNAs: a valuable biomarker for metabolic syndrome.Molecular genetics and genomics : MGG · 2022
    Review
  17. Review
  18. Review
  19. Long Non-coding RNAs (lncRNAs), A New Target in Stroke.Cellular and molecular neurobiology · 2022
    Review
  20. Co-upregulation ofJournal of dental sciences · 2022
    Article

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Ye SuMatthew Mailing Centre for Translational Transplantation Studies, Lawson Health Research Institute, London Health Sciences Centre, University of Western Ontario, London, Ontario, Canada.
Haijiang WuKey Laboratory of Kidney Diseases, Department of Pathology, Hebei Medical University, Shijiazhuang, China.
Alexander PavloskyMatthew Mailing Centre for Translational Transplantation Studies, Lawson Health Research Institute, London Health Sciences Centre, University of Western Ontario, London, Ontario, Canada.
Ling-Lin ZouDepartment of Oncology, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.
Xinna DengDepartment of Oncology and Immunotherapy, Hebei General Hospital, Shijiazhuang, China.
Zhu-Xu ZhangMatthew Mailing Centre for Translational Transplantation Studies, Lawson Health Research Institute, London Health Sciences Centre, University of Western Ontario, London, Ontario, Canada.
Anthony M JevnikarMatthew Mailing Centre for Translational Transplantation Studies, Lawson Health Research Institute, London Health Sciences Centre, University of Western Ontario, London, Ontario, Canada.
London Health Sciences Centre · CAWestern University · CAAffiliated Hospital of Southwest Medical University · CNHebei General Hospital · CNHebei Medical University · CN

Funding

CIHR MOP-111180CIHR MOP-115048
6 · The paper itself

Abstract

Non-coding RNA (ncRNA) comprises a substantial portion of primary transcripts that are generated by genomic transcription, but are not translated into protein. The possible functions of these once considered 'junk' molecules have incited considerable interest and new insights have emerged. The two major members of ncRNAs, namely micro RNA (miRNA) and long non-coding RNA (lncRNA), have important regulatory roles in gene expression and many important physiological processes, which has recently been extended to programmed cell death. The previous paradigm of programmed cell death only by apoptosis has recently expanded to include modalities of regulated necrosis (RN), and particularly necroptosis. However, most research efforts in this field have been on protein regulators, leaving the role of ncRNAs largely unexplored. In this review, we discuss important findings concerning miRNAs and lncRNAs that modulate apoptosis and RN pathways, as well as the miRNA-lncRNA interactions that affect cell death regulation.

Indexed as

AnimalsCell DeathHumansMicroRNAsModels, BiologicalRNA, UntranslatedMicroRNAsRNA, Untranslated

Identifiers

PMID27512954
PMCPMC5108314
OpenAlexW2515293382

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.