Evidence map›Paper›PMID 27512889›Full record

ArticleMedicine2016

Cancer in first-degree relatives of people with celiac disease.

Louise Emilsson, Joseph A Murray, Daniel A Leffler, Jonas F Ludvigsson

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Coeliac disease: complications and comorbidities.Nature reviews. Gastroenterology & hepatology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Louise EmilssonDepartment of Health Management and Health Economy, Institute of Health and Society, University of Oslo, Norway Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA Primary care research unit, Vårdcentralen Värmlands Nysäter, Värmland County, Sweden Division of Gastroenterology and Hepatology, Department of Immunology, Mayo Clinic, Rochester, MN Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Stockholm Department of Pediatrics, Örebro University Hospital, Örebro, Sweden Division of Epidemiology and Public Health, School of Medicine, University of Nottingham, Clinical Sciences Building 2, City Hospital, Nottingham, UK Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY.
Joseph A Murray
Daniel A Leffler
Jonas F Ludvigsson
Karolinska Institutet · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCeliac disease (CD) has been linked to cancer, especially lymphoproliferative malignancy (LPM). Earlier research has shown that first-degree relatives (FDRs) to individuals with CD are at increased risk of autoimmunity including CD, but data on their risk of cancer are scarce and contradictory. We aimed to assess whether Swedish FDRs to individuals with CD are at increased risk of cancer.

methodsIndividuals with CD (identified through biopsy reports equal to Marsh grade III) were matched on sex, age, county, and calendar year with up to 5 control individuals. All FDRs (father, mother, sibling, offspring) of CD individuals ("celiac FDRs": n = 109,391) and controls (n = 548,465) were identified through Swedish healthcare registries. Through Cox regression, we calculated hazard ratios (HRs) for cancer incidence (all cancer, breast cancer, gastrointestinal cancer, and LPM).

resultsDuring follow-up, celiac FDRs experienced 10,750 unique cancers as opposed to 54,686 in-control FDRs. Celiac FDRs were at a slightly lower risk of any cancer (HR 0.97, 95% confidence interval [CI] 0.95-0.99), partially due to the lower risk of breast cancer (HR 0.92, 95% CI 0.87-0.98). The relative risks of LPM (HR 0.99, 95% CI 0.91-1.08) and gastrointestinal cancer (HR 0.98, 95%CI 0.93-1.03) were both close to 1. As opposed to earlier research, we found no excess risk of LPM in siblings to individuals with CD (HR 0.98, 95% CI 0.81-1.19).

conclusionCeliac FDRs are not at increased risk of cancer, including LPM, arguing that shared genetics is unlikely to explain previous reports of an excess risk of LPM in patients with CD.

Indexed as

AdolescentAdultAgedCase-Control StudiesCeliac DiseaseChildFamilyFemaleHumansMaleMiddle AgedNeoplasmsProportional Hazards ModelsRisk FactorsSwedenYoung Adult

Identifiers

PMID27512889
PMCPMC4985344
OpenAlexW2508957117

What OpenQuestion holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.