ArticleSpringerPlus2016
Novel technique of vulvo-vaginal rejuvenation by lipofilling and injection of combined platelet-rich-plasma and hyaluronic acid: a case-report.
Article in SpringerPlus, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07306611 (Regenerative Treatment of Female Genital Atrophy), which is not on this map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Regenerative Treatment of Female Genital Atrophy
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Patient-reported outcomes and measures for vaginal relaxation syndrome management: a systematic review.Health and quality of life outcomes · 2025Pooled it
- Injection Treatments for Vulvovaginal Atrophy of Menopause: A Systematic Review.Aesthetic plastic surgery · 2023Pooled it
- Sexual Quality of Life in Postmenopausal Women: A Comparative Randomized Controlled Trial of Intravaginal PRP Therapy Versus Local Hormonal Treatments.Medicina (Kaunas, Lithuania) · 2025Trial
- Bibliometric Analysis of Platelet-Rich Plasma Treatment for Hair Restoration, Facial Rejuvenation, Dental Procedures, and Gynecological Rejuvenation.Skin appendage disorders · 2025Article
- Evaluation of the efficacy of injectable platelet-rich fibrin in genitourinary syndrome of menopause.Journal of the Turkish German Gynecological Association · 2025Article
- A Bibliometric and Visualisation Analysis on the Research of Female Genital Plastic Surgery Based on the Web of Science Core Collection Database.Aesthetic plastic surgery · 2024Review
- Article
- Role of platelet-rich plasma in pelvic floor disorders: A systematic review.International journal of reproductive biomedicine · 2023Review
- Efficacy and Safety of Platelet-Rich Plasma Injections for the Treatment of Female Sexual Dysfunction and Stress Urinary Incontinence: A Systematic Review.Biomedicines · 2023Review
- Treatment of Vulvovaginal Laxity by Electroporation: The Jett Plasma Medical for Her II Study.Journal of clinical medicine · 2023Article
- Current Perspectives in Vaginal Laxity Measurement: A Scoping Review.Archives of plastic surgery · 2023Article
- A Novel Technique Combining Human Acellular Dermal Matrix (HADM) and Enriched Platelet Therapy (EPT) for the Treatment of Vaginal Laxity: A Single-Arm, Observational Study.Aesthetic plastic surgery · 2022Observational
- V-Y advancement flap to correct a perineal defect after an episiotomy dehiscence.International urogynecology journal · 2021Article
- Materials Selection for the Injection into Vaginal Wall for Treatment of Vaginal Atrophy.Aesthetic plastic surgery · 2021Review
- Regenerative Medicine, Stem Cell Therapies, and Platelet-Rich Plasma: Where Is the Evidence?Aesthetic surgery journal · 2020Article
- First Use of Thermal Stabilized Hyaluronic Acid Injection in One-Year Follow-Up Patients with Genitourinary Syndrome.Medical devices (Auckland, N.Z.) · 2020Article
- Vaginal rejuvenation: From scalpel to wands.International journal of women's dermatology · 2019Article
- Vaginal rejuvenation: current perspectives.International journal of women's health · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo describe a new surgical procedure and its results: the vulvo-vaginal rejuvenation by lipofilling and an injection of combined platelet-rich-plasma (PRP) and hyaluronic acid (HA). Sexual life for women is affected by the effect of aging and by post partum traumatism. There are no standard non-invasive treatments to offer to improve the trophic and dimensional alterations of the vulvo-vaginal area. The surgical procedure consists in a vaginoplasty by lipofilling of the posterior vaginal wall far from the vascular axes and with an injection of an injection of combined PRP and HA subcutaneously in the perineum. To illustrate the technique and evaluate its results, we present the case of a 39 year-old-female with history of episiotomy presented that vaginal laxity resistant to physical therapy. To assess the results regarding the sexual quality of life we used the modified Stabbatsberg self-rating scale.
findingsThere were no intra-operative complications with this simple procedure. During follow-up we observed an improvement in the modified Stabbatsberg scale and a vulvo-perineal rejuvenation by improving the vaginal trophicity and restoring a normal vaginal caliber. No post-operative complications occurred.
conclusionsVulvo-vaginal rejuvenation lipofilling and an injection of combined platelet-rich-plasma and hyaluronic acid is a minimally invasive technique that is safe and easy to perform. Further studies are necessary to assess more thoroughly the effectiveness and safety of this procedure and assess medium and long term results.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.