ArticleAnnals of thoracic medicine
Association of human leukocyte antigen class II alleles with severe Middle East respiratory syndrome-coronavirus infection.
Article in Annals of thoracic medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 2 of them syntheses that pooled it.
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Who cites it
52 citing papers in PubMed, 2 syntheses or guidelines pooled it, 87 citations in OpenAlex.
- Risk HLA alleles in South America and potential new epitopes for SARS-CoV2.Human immunology · 2021Pooled it
- Genetic variants of the human host influencing the coronavirus-associated phenotypes (SARS, MERS and COVID-19): rapid systematic review and field synopsis.Human genomics · 2020Pooled it
- HLA Class I and II Variants as Potential Determinants of Clinical Severity and Mortality in Patients with COVID-19: A Prospective Study from Saudi Arabia.Biomedicines · 2026Article
- Article
- Repercussion of SARS-CoV-2 on the Sexual Function in Males: An Updated Review.Infectious disorders drug targets · 2025Review
- The Influence of HLA Polymorphisms on the Severity of COVID-19 in the Romanian Population.International journal of molecular sciences · 2024Article
- HLA-B27 did not protect against COVID-19 in patients with axial spondyloarthritis - data from the ReumaCov-Brasil Registry.Advances in rheumatology (London, England) · 2023Article
- COVID-19 annual update: a narrative review.Human genomics · 2023Review
- Effect of probiotics as an immune modulator for the management of COVID-19.Archives of microbiology · 2023Article
- Targeted capture enrichment and sequencing identifies HLA variants associated with the severity of COVID-19.Genes & genomics · 2023Article
- Molecular Understanding of ACE-2 and HLA-Conferred Differential Susceptibility to COVID-19: Host-Directed Insights Opening New Windows in COVID-19 Therapeutics.Journal of clinical medicine · 2023Review
- Effects of Biological Sex and Pregnancy on SARS-CoV-2 Pathogenesis and Vaccine Outcomes.Current topics in microbiology and immunology · 2023Article
- Exome-Wide Association Study Reveals Host Genetic Variants Likely Associated with the Severity of COVID-19 in Patients of European Ancestry.Life (Basel, Switzerland) · 2022Article
- Clinical implications of host genetic variation and susceptibility to severe or critical COVID-19.Genome medicine · 2022Review
- Association of HLA class I and II genes with Middle East respiratory syndrome coronavirus infection in Koreans.Immunity, inflammation and disease · 2022Article
- Molecular Insights into the Crosstalk Between Immune Inflammation Nexus and SARS-CoV-2 Virus.Current microbiology · 2021Review
- Association between HLA genotypes and COVID-19 susceptibility, severity and progression: a comprehensive review of the literature.European journal of medical research · 2021Review
- Article
- Antigen presentation in SARS-CoV-2 infection: the role of class I HLA and ERAP polymorphisms.Human immunology · 2021Review
- MHC Haplotyping of SARS-CoV-2 Patients: HLA Subtypes Are Not Associated with the Presence and Severity of COVID-19 in the Israeli Population.Journal of clinical immunology · 2021Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMiddle East Respiratory Syndrome (MERS) is a disease of the lower respiratory tract and is characterized by high mortality. It is caused by a beta coronavirus (CoV) referred to as MERS-CoV. Majority of MERS-CoV cases have been reported from Saudi Arabia.
aimWe investigated the human leukocyte antigen (HLA) Class II alleles in patients with severe MERS who were admitted in our Intensive Care Unit.
methodsA total of 23 Saudi patients with severe MERS-CoV infection were typed for HLA class II, results were compared with those of 161 healthy controls.
resultsTwo HLA class II alleles were associated with the disease; HLA-DRB1*11:01 and DQB1*02:02, but not with the disease outcome.
conclusionsOur results suggest that the HLA-DRB1*11:01 and DQB1*02:02 may be associated with susceptibility to MERS.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.