ArticleAnnals of thoracic medicine
A systematic review on prevalence and risk factors associated with treatment- emergent central sleep apnea.
Article in Annals of thoracic medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 70 citations in OpenAlex.
- Therapeutic effects of oxygen inhalation for obstructive sleep apnea patients with high carotid body chemosensitivity.BMC pulmonary medicine · 2026Trial
- Unveiling the complexity: predicting long-term CPAP adherence among patients with moderate to severe OSA undergoing 'Interval' CPAP Titration study. A prospective randomised study.Sleep & breathing = Schlaf & Atmung · 2025Trial
- Treatment-emergent central sleep apnea resolves with lower inspiratory pressure.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025Article
- Impact of Hypopnoea Classifications on the Assessment of Sleep Disordered Breathing in Heart Failure.Cardiac failure review · 2025Review
- Waves Under the Surface? Finding "Centralness" with Self-Similarity.Annals of the American Thoracic Society · 2025Article
- Management of central sleep apnoea: a review of non-hypercapnic causes.Breathe (Sheffield, England) · 2024Review
- Central sleep apnoea: not just one phenotype.European respiratory review : an official journal of the European Respiratory Society · 2024Review
- The prevalence of treatment-emergent central sleep apnea with mandibular advancement device therapy.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2023Article
- International Consensus Statement on Obstructive Sleep Apnea.International forum of allergy & rhinology · 2023Review
- Central Sleep Apnea in Adults: Diagnosis and Treatment.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2023Article
- A longitudinal study of the accuracy of positive airway pressure therapy machine-detected apnea-hypopnea events.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022Article
- Treatment-emergent central sleep apnoea managed by CPAP with adjunctive acetazolamide: A case report.Respirology case reports · 2022Article
- The Evaluation of APAP Titration Results: Good Titration Versus TECSA and Unacceptable Titration.Turkish thoracic journal · 2021Article
- Titration studies overestimate continuous positive airway pressure requirements in uncomplicated obstructive sleep apnea.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2021Article
- A case of Cheyne-Stokes breathing emerging in a patient with atrial fibrillation and an implanted hypoglossal nerve stimulator.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2021Article
- Review
- An Update on Assessment, Therapeutic Management, and Patents on Insomnia.BioMed research international · 2021Review
- Postoperative outcomes in patients with treatment-emergent central sleep apnea: a case series.Journal of anesthesia · 2020Article
- Frequency and outcomes of primary central sleep apnea in a population-based study.Sleep medicine · 2020Review
- Adaptive Servo-Ventilation: A Comprehensive Descriptive Study in the Geneva Lake Area.Frontiers in medicine · 2020Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionTreatment-emergent central sleep apnea (TECSA) is the appearance of central apneas and hypopneas after significant resolution of the obstructive events has been attained using positive airway pressure (PAP) therapy. The aim of the study was to determine the prevalence of TECSA and to understand what factors are associated with its development.
methodsPubMed, MEDLINE, Scopus, Web of Science and Cochran Library databases were searched with Mesh headings to locate studies linking TECSA and obstructive sleep apnea (OSA).
resultsNine studies were identified that reported the prevalence of TECSA ranging from 5.0% to 20.3%. Prevalence of TECSA for studies using only full night titration was between 5.0% and 12.1% where as it was between 6.5% and 20.3% for studies using split-night polysomnogram. The mean effective continuous PAP (CPAP) setting varied between 7.5 cm and 15.2 cm of water for patients in TECSA group and between 7.4 cm and 13.6 cm of water for the group without TECSA.
conclusionsThe aggregate point prevalence of TECSA is about 8% with the estimated range varying from 5% to 20% in patients with untreated OSA. The prevalence tends to be higher for split-night studies compared to full night titration studies. TECSA can occur at any CPAP setting although extremely high CPAP settings could increase the likelihood. Male gender, higher baseline apnea-hypopnea index, and central apnea index at the time of diagnostic study could be associated with the development of TECSA at a subsequent titration study.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.