ReviewObstetric medicine2015
Pregnancy in women with inherited metabolic disease.
Review in Obstetric medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
- Integrated metabolome analysis reveals novel connections between maternal fecal metabolome and the neonatal blood metabolome in women with gestational diabetes mellitus.Scientific reports · 2020Trial
- The multifaceted challenges faced by women in the field of inherited metabolic disorders.Orphanet journal of rare diseases · 2025Review
- Diabetic and hypertensive disorders following early pregnancy loss: a systematic review and meta-analysis.EClinicalMedicine · 2024Review
- Rare diseases: still on the fringes of universal health coverage in Europe.The Lancet regional health. Europe · 2024Review
- Updating an Overview of Teratology.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Review
- Successful pregnancy and childbirth without metabolic abnormality in a patient with holocarboxylase synthetase deficiency.Molecular genetics and metabolism reports · 2022Article
- Considerations for prenatal and postpartum management of a female patient with ornithine transcarbamylase deficiency.Molecular genetics and metabolism reports · 2022Article
- Very long-term outcomes in 23 patients with cblA type methylmalonic acidemia.Journal of inherited metabolic disease · 2022Article
- The Impact of the Quality of Nutrition and Lifestyle in the Reproductive Years of Women with PKU on the Long-Term Health of Their Children.Nutrients · 2022Review
- Moving through adulthood: The lived experience of Irish adults with PKU.Frontiers in psychology · 2022Article
- Physical and Neurological Development of a Girl Born to a Mother with Methylmalonic Acidemia and Kidney Transplantation and Review of the Literature.Children (Basel, Switzerland) · 2021Review
- Role of early management of hyperornithinaemia-hyperammonaemia-homocitrullinuria syndrome in pregnancy.BMJ case reports · 2021Article
- Untargeted analysis of first trimester serum to reveal biomarkers of pregnancy complications: a case-control discovery phase study.Scientific reports · 2021Article
- Hyperornithinemia-hyperammonemia-homocitrullinuria syndrome in pregnancy: Considerations for management and review of the literature.JIMD reports · 2019Article
- Pregnancy management and outcome in patients with four different tetrahydrobiopterin disorders.Journal of inherited metabolic disease · 2018Article
- Maternal Genetic Disorders in Pregnancy.Obstetrics and gynecology clinics of North America · 2018Review
- Successful Pregnancy in a Young Woman with Multiple Acyl-CoA Dehydrogenase Deficiency.JIMD reports · 2018Article
- Treatable inherited rare movement disorders.Movement disorders : official journal of the Movement Disorder Society · 2018Review
- Successful Pregnancy in a Patient with L-Amino Acid Decarboxylase Deficiency: Therapeutic Management and Clinical Outcome.Movement disorders clinical practiceArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An increasing number of women with rare inherited disorders of metabolism are becoming pregnant. Whilst, in general, outcomes for women and their children are good, there are issues that need to be considered. Due to the rarity of many conditions, there is limited specific guidance available on best management. Prepregnancy counselling with information on inheritance, options for reproduction, teratogenicity risk, potential impact on maternal health and long-term health of children should be offered. With appropriate specialist management, the teratogenic risk of conditions such as maternal phenylketonuria (PKU) can be eliminated, and the risk of metabolic decompensation in other disorders of intoxication or energy metabolism significantly reduced. Newer therapies, such as enzyme replacement therapy, appear to be safe in pregnancy, but specific advice should be sought. Multidisciplinary management, and close liaison between obstetricians and other specialists is required for women in whom there is cardiac, renal, respiratory, joint or other organ involvement.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.