Evidence map›Paper›PMID 27512368›Full record

ReviewFrontiers in human neuroscience2016

Non-invasive Brain Stimulation, a Tool to Revert Maladaptive Plasticity in Neuropathic Pain.

Antonino Naro, Demetrio Milardi, Margherita Russo, Carmen Terranova, Vincenzo Rizzo, Alberto Cacciola, Silvia Marino, Rocco S Calabro, Angelo Quartarone

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Frontiers in human neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04234555 (What is the Nature of Pelvic Floor Muscle Involvement in Dyspareunia?), which is not on this map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04234555 completednot on this mapstarted 2021, after this paper: background citation

What is the Nature of Pelvic Floor Muscle Involvement in Dyspareunia?

TypeobservationalSponsorUniversity of OttawaRan2021 to 2023Enrolled85ConditionsDyspareuniaArmsCorticomotor excitability to the pelvic floor muscles, Pelvic floor muscle response to pressure applied at the vulvar vestibule, Pressure pain threshold (PPS), Temporal summation of pain, Tonic, phasic and reflex activation of the pelvic floor muscles (PFMs)
3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.

  1. Pooled it
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  13. Article
  14. Motor Cortex Stimulation for Deafferentation Pain.Current pain and headache reports · 2018
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Antonino NaroIRCCS Centro Neurolesi "Bonino-Pulejo" Messina, Italy.
Demetrio MilardiIRCCS Centro Neurolesi "Bonino-Pulejo"Messina, Italy; Department of Biomedical, Dental Sciences and Morphological and Functional Images, University of MessinaMessina, Italy.
Margherita RussoIRCCS Centro Neurolesi "Bonino-Pulejo" Messina, Italy.
Carmen TerranovaDepartment of Clinical and Experimental Medicine, University of Messina Messina, Italy.
Vincenzo RizzoDepartment of Clinical and Experimental Medicine, University of Messina Messina, Italy.
Alberto CacciolaIRCCS Centro Neurolesi "Bonino-Pulejo"Messina, Italy; Department of Biomedical, Dental Sciences and Morphological and Functional Images, University of MessinaMessina, Italy.
Silvia MarinoIRCCS Centro Neurolesi "Bonino-Pulejo" Messina, Italy.
Rocco S CalabroIRCCS Centro Neurolesi "Bonino-Pulejo" Messina, Italy.
Angelo QuartaroneIRCCS Centro Neurolesi "Bonino-Pulejo"Messina, Italy; Department of Biomedical, Dental Sciences and Morphological and Functional Images, University of MessinaMessina, Italy.
Centro Neurolesi Bonino Pulejo · ITUniversity of Messina · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuromodulatory effects of non-invasive brain stimulation (NIBS) have been extensively studied in chronic pain. A hypothetic mechanism of action would be to prevent or revert the ongoing maladaptive plasticity within the pain matrix. In this review, the authors discuss the mechanisms underlying the development of maladaptive plasticity in patients with chronic pain and the putative mechanisms of NIBS in modulating synaptic plasticity in neuropathic pain conditions.

Indexed as

neuropathic painNIBSplasticitytDCSTMS

Identifiers

PMID27512368
PMCPMC4961691
OpenAlexW2490665638

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.