ArticleEuropean journal of plastic surgery
Negative pressure wound therapy induces early wound healing by increased and accelerated expression of vascular endothelial growth factor receptors.
Article in European journal of plastic surgery. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 4 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Negative pressure wound therapy for surgical wounds healing by primary closure.The Cochrane database of systematic reviews · 2022Pooled it
- Negative pressure wound therapy for surgical wounds healing by primary closure.The Cochrane database of systematic reviews · 2020Pooled it
- Negative pressure wound therapy for surgical wounds healing by primary closure.The Cochrane database of systematic reviews · 2020Pooled it
- Negative pressure wound therapy for surgical wounds healing by primary closure.The Cochrane database of systematic reviews · 2019Pooled it
- Negative pressure wound therapy in the treatment of diabetic foot ulcers may be mediated through differential gene expression.Acta diabetologica · 2019Trial
- Negative pressure mechanical signal increases the phosphorylation of eNOS Ser1177 by upregulating HSP90 expression to promote wound angiogenesis.Journal of advanced research · 2026Article
- The Efficacy of Negative Pressure Wound Therapy (NPWT) on Healing of Diabetic Foot Ulcers: A Literature Review.Current diabetes reviews · 2024Review
- The Effect of Negative Pressure on Wound Healing and Regeneration in Closed Incisions under High Tension: Evidence from Animal Studies and Clinical Experience.Journal of clinical medicine · 2022Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNegative pressure wound therapy (NPWT) is commonly used to accelerate wound healing, especially following thoracic surgery; however, the mechanism remains elusive. Given the important role of vasculogenesis in wound healing, we evaluated whether NPWT might accelerate vasculogenesis in the wound area. Toward this end, we investigated the temporal expression of vascular endothelial growth factor receptors (VEGFRs) in an NPWT-wound healing rabbit model.
methodsRabbits were divided into an NPWT group and a non-NPWT control group, and tissue samples were collected around wounds made in the skin of each rabbit at five time points: 0, 7, 14, 21, and 28 days after wound creation. Cryopreserved samples were then immunostained and subject to image analysis to evaluate the temporal changes in VEGFR1, VEGFR2, and VEGFR3 expression in the wound-healing process.
resultsResults of histological analysis of the temporal changes in VEGFR expression throughout the healing process showed that compared to the control group, VEGFR2 and VEGFR3 were abundantly and rapidly expressed in the NPWT group, and were expressed earlier than VEGFR1.
conclusionsNPWT promotes the expression of VEGFR2 and VEGFR3, which provides insight into the mechanism by which NPWT accelerates wound healing. Level of Evidence: Not ratable.
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Registered trials
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