Evidence map›Paper›PMID 27512023›Full record

ArticleJournal of neurophysiology2016

Sciatic nerve stimulation activates the retrotrapezoid nucleus in anesthetized rats.

Roy Kanbar, Ruth L Stornetta, Patrice G Guyenet

Abstract read
In one paragraph

Article in Journal of neurophysiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Obligatory neural feedback control of exercise cardiorespiratory function and performance.Journal of applied physiology (Bethesda, Md. : 1985) · 2025
    Review
  2. Interactions between Arousal State and COThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Central respiratory chemoreception.Handbook of clinical neurology · 2022
    Review
  10. Article
  11. Article
  12. Ganglionic GFAPJCI insight · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Roy KanbarDepartment of Pharmaceutical Sciences, School of Pharmacy, Lebanese American University, Byblos, Lebanon; and.
Ruth L StornettaDepartment of Pharmacology, School of Medicine, University of Virginia, Charlottesville, Virginia.
Patrice G GuyenetDepartment of Pharmacology, School of Medicine, University of Virginia, Charlottesville, Virginia pgg@virginia.edu.

Funding

Retrotrapezoid nucleus and central chemoreceptionR01HL074011 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI GUYENET, PATRICE G. · 2003 to 2018
$6.6M
Organization of Central Sympathic PathwaysR01HL028785 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI STORNETTA, RUTH L · 1985 to 2020
$5.0M
NHLBI NIH HHS R01 HL028785NHLBI NIH HHS R01 HL074011
6 · The paper itself

Abstract

Retrotrapezoid nucleus (RTN) neurons sustain breathing automaticity. These neurons have chemoreceptor properties, but their firing is also regulated by multiple synaptic inputs of uncertain function. Here we test whether RTN neurons, like neighboring presympathetic neurons, are excited by somatic afferent stimulation. Experiments were performed in Inactin-anesthetized, bilaterally vagotomized, paralyzed, mechanically ventilated Sprague-Dawley rats. End-expiratory CO

Indexed as

AnesthesiaAction PotentialsAnimalsChemoreceptor CellsElectric StimulationMaleRatsRats, Sprague-DawleyRespiratory CenterRespiratory MechanicsSciatic Nerveexercise hyperpneanociceptionretrotrapezoid nucleussomatic input

Identifiers

PMID27512023
PMCPMC5102315

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.